Zhou Zheng, Liu Lixiang, Jin Meihui, Ren Bingxuan, Meng Fangang, Wang Dandan, Li Jianshuang, Li Baoxiang, He Yanhong, Li Fan, Shen Hongmei
Centre for Endemic Disease Control, Chinese Centre for Disease Control and Prevention, Harbin Medical University, Harbin, Heilongjiang150081, China.
National Health Commission and Education Bureau of Heilongjiang Province, Key Laboratory of Etiology and Epidemiology, Harbin Medical University (23618504), Harbin, People's Republic of China.
Br J Nutr. 2022 Jul 25:1-11. doi: 10.1017/S0007114522002367.
The aim of this study was to explore the status of thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TGAb) in three areas with differing water iodine concentrations; and to discuss the relationships between these two thyroid antibodies and thyroid diseases in the three areas. We investigated 2503 adults from three areas. Urinary iodine concentrations, thyroid stimulating hormone (TSH), free thyroxine (FT), free triiodothyronine (FT), TPOAb, TGAb and thyroid volume (TV) were measured, and thyroid ultrasonography was performed. The positivity rates of TGAb(+), TPOAb(+) and TGAb(+) and TPOAb(+) or TGAb(+) were significantly higher in iodine fortification (IF) areas than iodine adequate (IA) areas (all < 0·05). In IF and iodine excess areas, the positivity rates of TPOAb(+), TGAb(+) and TPOAb(+) or TGAb(+) significantly increased with age (all for trend < 0·05). The levels of TSH, TV and the prevalence of overt hypothyroidism, subclinical hypothyroidism and goitre were significantly elevated in the thyroid antibody-positive groups in the three areas, but the FT was diminished (all < 0·010). Positivity for TPOAb and TGAb was associated with an increased risk of subclinical hypothyroidism in the three areas. In areas with different median water iodine, positivity for both TPOAb and TGAb was associated with elevated TSH values. Notably, with the increased levels of TPOAb, the frequency of abnormally elevated TSH increased dramatically in the three areas.
本研究旨在探讨三个水碘浓度不同地区的甲状腺过氧化物酶抗体（TPOAb）和甲状腺球蛋白抗体（TGAb）的状况；并讨论这两种甲状腺抗体与三个地区甲状腺疾病之间的关系。我们调查了来自三个地区的2503名成年人。测量了尿碘浓度、促甲状腺激素（TSH）、游离甲状腺素（FT）、游离三碘甲状腺原氨酸（FT）、TPOAb、TGAb和甲状腺体积（TV），并进行了甲状腺超声检查。碘强化（IF）地区TGAb（+）、TPOAb（+）以及TGAb（+）和TPOAb（+）或TGAb（+）的阳性率显著高于碘充足（IA）地区（均<0.05）。在IF地区和碘过量地区，TPOAb（+）、TGAb（+）以及TPOAb（+）或TGAb（+）的阳性率随年龄显著增加（均趋势<0.05）。三个地区甲状腺抗体阳性组的TSH水平、TV以及显性甲状腺功能减退、亚临床甲状腺功能减退和甲状腺肿的患病率显著升高，但FT降低（均<0.010）。三个地区中，TPOAb和TGAb阳性与亚临床甲状腺功能减退风险增加相关。在水碘中位数不同的地区，TPOAb和TGAb阳性均与TSH值升高相关。值得注意的是，随着TPOAb水平升高，三个地区TSH异常升高的频率急剧增加。
