Gansu center for diseases control and prevention, Lanzhou Gansu, China. Email:
The first people hospital of Lanzhou city, Lanzhou Gansu, China.
Asia Pac J Clin Nutr. 2021;30(1):99-103. doi: 10.6133/apjcn.202103_30(1).0012.
This study was undertaken to evaluate the status of iodine nutrition and thyroid function of women at different phases of gestation in an iodine sufficient rural area.
215 pregnant women in different trimesters were consecutively enrolled in iodine sufficient rural areas of Yongjing county of Gansu province, China. The blood samples and random urine samples were collected from them, and serum thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxin (FT4), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb) and urinary iodine were measured.
Median Urinary Iodine (MUI) of three groups of pregnant women (first, second and third trimester) were 190 μg/L, 153 μg/L and 145 μg/L respectively. With the increase of gestational age, the level of FT3 decreased. And the FT3 level in the first trimester was higher than those in the second and third trimester. There was a U-shaped curve seen between the TSH levels and the gestational age. The medians of TgAb and TPOAb appeared the lowest in the first trimester．Significant difference was seen in TgAb and TPOAb levels of the three groups of pregnant women. The incidence of thyroid function disorder was 1.86%, including subclinical hypothyroidism accounted for 1.40% and hypothyroidism accounted for 0.47%. The incidence of thyroid function disorder mainly appeared in the early pregnancy. Abnormal FT3, TSH, positive TgAb and TPOAb were mainly seen during early pregnancy.
The levels of serum TSH and thyroid hormones fluctuate at the different phases of pregnancy. With the increase of gestational age, the incidence of iodine deficiency also increased. Abnormal thyroid hormones, TSH, positive TgAb and TPOAb were mainly existed in the early pregnancy.
本研究旨在评估碘充足的农村地区不同孕期妇女的碘营养和甲状腺功能状况。
连续纳入中国甘肃省永靖县碘充足农村地区的 215 名孕妇，采集其血样和随机尿样，检测血清促甲状腺激素（TSH）、游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）、甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）和尿碘。
三组孕妇（孕早期、孕中期和孕晚期）的中位数尿碘（MUI）分别为 190μg/L、153μg/L 和 145μg/L。随着妊娠周数的增加，FT3 水平逐渐下降，且孕早期 FT3 水平高于孕中期和孕晚期。TSH 水平与妊娠周数之间呈 U 型曲线。TgAb 和 TPOAb 的中位数在孕早期最低。三组孕妇的 TgAb 和 TPOAb 水平存在显著差异。甲状腺功能障碍的发生率为 1.86%，其中亚临床甲状腺功能减退症占 1.40%，甲状腺功能减退症占 0.47%。甲状腺功能障碍的发生率主要出现在孕早期。孕早期主要出现 FT3、TSH、TgAb 和 TPOAb 阳性异常。
血清 TSH 和甲状腺激素水平在妊娠的不同阶段波动。随着妊娠周数的增加，碘缺乏的发生率也增加。异常的甲状腺激素、TSH、TgAb 和 TPOAb 主要存在于孕早期。
