表面重构溶菌酶增强抗革兰氏阴性菌的抗菌活性而无累积耐药性。
Enhanced antibacterial activity of surface re-engineered lysozyme against Gram-negative bacteria without accumulated resistance.
机构信息
School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, 150001, China.
出版信息
Biomater Sci. 2022 Aug 9;10(16):4474-4478. doi: 10.1039/d2bm00868h.
PMID:35876097
Abstract
In this study, we show a way to improve the antibacterial activity of lysozyme by incorporating guanidino functional groups onto its surface (Lyz-Gua), which could treat pathogenic bacteria without accumulated resistance and shows advantages over commercial antibiotics.
摘要
在这项研究中，我们展示了一种通过在溶菌酶表面引入胍基官能团来提高其抗菌活性的方法（Lyz-Gua），它可以治疗致病细菌，而不会产生累积耐药性，并优于商业抗生素。
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