Bukharin O V, Usviatsov B Ia, Zheltova V I, Boldyreva L G
Antibiotiki. 1978 Nov;23(11):997-1002.
A synergistic effect of the antibacterial action of the lysozyme combination with various antibiotics against gram-positive and gram-negative microorganisms was found. The intensifying effect of lysozyme on its combination with antibiotics was more evident with respect to gram-positive microbes and less evident with respect to gram-negative organisms. The combinations os lysozyme with methicillin, lincomycin, oleandomycin or erythromycin proved to be most active against staphylococci. A high synergistic effect against streptococci was observed with the use of the lysozyme combination with benzylpenicillin, morphocycline, oleandomycin, ceporin or monomycin. The combination of lysozyme with macrolides had a maximum inhibitory effect on Coli bacteria.
发现溶菌酶与多种抗生素联合使用对革兰氏阳性菌和革兰氏阴性菌具有协同抗菌作用。溶菌酶与抗生素联合使用时，其增强作用对革兰氏阳性菌更为明显，对革兰氏阴性菌则不太明显。溶菌酶与甲氧西林、林可霉素、竹桃霉素或红霉素的联合使用对葡萄球菌最为有效。使用溶菌酶与苄青霉素、吗啉环素、竹桃霉素、头孢菌素或单霉素联合时，观察到对链球菌有很高的协同作用。溶菌酶与大环内酯类药物的联合使用对大肠杆菌具有最大抑制作用。
