Kidron D, Melamed E
Neurology. 1987 Jun;37(6):1009-11. doi: 10.1212/wnl.37.6.1009.
We studied various forms of dystonia associated with Parkinson's disease (PD) in 207 patients who were on levodopa therapy for more than 1 year. Dystonia, sometimes more than one type, occurred in 63 (30%). In five patients, dystonia preceded initiation of treatment. Fifteen patients had peak-dose dystonia, 33 had early-morning dystonia, and 20 had "off-period" dystonia. The different clinical features of the dystonias are presented and compared. Findings indicate that dystonia is a frequent feature of levodopa-treated PD patients.
我们对207名接受左旋多巴治疗超过1年的帕金森病（PD）患者中与帕金森病相关的各种形式的肌张力障碍进行了研究。肌张力障碍，有时不止一种类型，发生在63名（30%）患者中。在5名患者中，肌张力障碍在治疗开始前就已出现。15名患者有剂峰肌张力障碍，33名有清晨肌张力障碍，20名有“关期”肌张力障碍。文中呈现并比较了肌张力障碍的不同临床特征。研究结果表明，肌张力障碍是左旋多巴治疗的帕金森病患者的常见特征。
