Department of Biochemistry, Konya City Hospital, Konya, Türkiye.
Department of Genetics, Konya Training and Research Hospital, Konya, Türkiye.
Nucleosides Nucleotides Nucleic Acids. 2022;41(11):1224-1262. doi: 10.1080/15257770.2022.2098974. Epub 2022 Jul 23.
Ischemic stroke (IS) is a global health challenge leading to life-long disabilities or the deaths of patients. IS is a complex disease where genetic and environmental factors are both concerned with the pathophysiology of the condition. Here, we aimed to investigate various microRNA (miRNA) expressions and their targets in IS. A rapid and accurate diagnosis of acute IS is important to perform appropriate treatment. Therefore, there is a need for a more rapid and simple tool to carry out an acute diagnosis of IS. miRNAs are small RNA molecules serving as precious biomarkers due to their easy detection and stability in blood samples. The present systematic review aimed to summarize previous studies investigating several miRNA expressions and their targets in IS.
缺血性脑卒中（IS）是一个全球性的健康挑战，导致患者终身残疾或死亡。IS 是一种复杂的疾病，遗传和环境因素都与疾病的病理生理学有关。在这里，我们旨在研究 IS 中各种 microRNA（miRNA）的表达及其靶标。快速准确地诊断急性 IS 对于进行适当的治疗非常重要。因此，需要一种更快速、更简单的工具来进行急性 IS 的诊断。miRNAs 是作为宝贵生物标志物的小 RNA 分子，因为它们在血液样本中的检测和稳定性都很容易。本系统综述旨在总结之前研究缺血性脑卒中几种 miRNA 表达及其靶标的研究。
