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鲑鱼降钙素用于人类中重度高钙血症的急性治疗。

Salmon calcitonin in the acute treatment of moderate and severe hypercalcemia in man.

作者信息

Nilsson O, Almqvist S, Karlberg B E

出版信息

Acta Med Scand. 1978;204(4):249-52. doi: 10.1111/j.0954-6820.1978.tb08434.x.

Abstract

The effect of i.v. infusions with salmon calcitonin was evaluated in the treatment of acute hypercalcemia in 12 patients. Clinical improvement and a less critical level of serum calcium were achieved within 24 hours for eight of the patients, for another two after treatment for 48 hours. In malignant conditions (six patients) calcitonin was less effective, which could be evaluated within 24 hours. In addition to rehydration, the rapid onset of action and the lack of side-effects make calcitonin a drug of first choice in the treatment of acute hypercalcemia.

摘要

对12例急性高钙血症患者静脉输注鲑鱼降钙素的疗效进行了评估。8例患者在24小时内临床症状改善,血清钙水平降至不那么危急的程度,另外2例在治疗48小时后症状改善。在恶性疾病患者(6例)中,降钙素疗效较差,这在24小时内即可评估。除补液外,降钙素起效迅速且无副作用,使其成为治疗急性高钙血症的首选药物。

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