关于基因突变、少牙症和牙科研究中伦理声明的文章概况。
The Profile of Articles on Mutations, Oligodontia, and Ethical Statements in Dental Research.
机构信息
Department of Dental Public Health and Professional Practice, School of Dentistry, West Virginia University, 104a Health Sciences Addition, PO Box 9415, Morgantown, WV 26506, USA.
出版信息
J Empir Res Hum Res Ethics. 2022 Oct;17(4):412-425. doi: 10.1177/15562646221116801. Epub 2022 Jul 25.
PURPOSE
Editors often require ethical statements in research publications. This is particularly important with genetic data where discrimination may occur upon data disclosures. The purpose of this research is to determine if there was a positive trend of publishing ethical statements in dental genetic research. The study is limited to AXIN2 mutations which may be associated with oligodontia and cancer.
METHODS
A MEDLINE search of 2011-2021 articles concerning AXIN2, oligodontia, and ethical statements was conducted. Reviews, nonhuman subject research, abstracts, and articles not written nor translated into English were excluded.
RESULTS
Forty-four studies were found; 10 excluded. There were 25 (75.8%) with ethical statements, and 25 (75.8%) with participant consent statements. There was no significant difference by year in ethical statements over the ten years (p = 0.094).
CONCLUSION
There is a need to encourage more ethical statements in publications especially for genetically sensitive topics to reassure readers of ethical practices.
目的
编辑人员通常要求在研究出版物中包含伦理声明。对于可能会因数据披露而引发歧视的遗传数据来说，这一点尤为重要。本研究旨在确定在牙科遗传研究中发表伦理声明是否存在积极趋势。该研究仅限于可能与少牙症和癌症相关的 AXIN2 突变。
方法
对 2011 年至 2021 年期间有关 AXIN2、少牙症和伦理声明的 MEDLINE 文章进行了搜索。排除了综述、非人体研究、摘要以及未用英文撰写或翻译的文章。
结果
共发现 44 项研究，其中 10 项被排除。有 25 项（75.8%）包含伦理声明，25 项（75.8%）包含参与者同意声明。在这十年中，伦理声明的发表在年份上没有显著差异（p=0.094）。
结论
需要鼓励出版物中包含更多的伦理声明，特别是对于遗传敏感主题，以向读者保证伦理实践。
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