Immunology Research Center, Mashhad University of Medical Sciences, Pardi's Campus, Azadi Square, Kalantari Blvd, Mashhad, Iran.
Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Pardi's Campus, Azadi Square, Kalantari Blvd, Mashhad, Iran.
Stem Cell Rev Rep. 2022 Dec;18(8):2781-2796. doi: 10.1007/s12015-022-10397-x. Epub 2022 Jul 25.
Lupus is known as a systemic immune-mediated disorder. Like other diseases in this category, its cause and definitive treatment remain unknown. Gold standard therapies, which mainly include immunosuppressive agents, have been able to have therapeutic effects on patients. However, a significant percentage of cases still do not respond to this kind of treatment, resulting in death from complications. Recently, a new source of non-hematopoietic cells, mesenchymal stem/stromal cells (MSCs), with the potency to re-establishment immune homeostasis and tissue regeneration, has been wildly used in both primary and clinical research. One of the remarkable features of MSCs is their anti-inflammatory and immunosuppressive properties and stimulating tissue differentiation programs. Under the influence of background signals, MSCs migrate to inflammatory bioactive substances and then regulate overactive immune responses to restore immune tolerance. MSCs have shown a two-way interaction with most immunocytes, which plays a significant role in resolving sterile inflammation. Restricting the entry of inflamed cells into the site of inflammation and re-educated infiltrated cells to achieve a tolerant phenotype have been reported as mechanisms of MSCs in tissue repair. Stimulation of the endogenous and tissue-dwelling stem cells in addition to releasing immunomodulatory agents, suggests MSCs transplantation as a potential modality in the treatment of future immune-mediated disorders.
狼疮被认为是一种系统性免疫介导的疾病。与该类别中的其他疾病一样，其病因和明确的治疗方法仍然未知。金标准疗法主要包括免疫抑制剂，已能够对患者产生治疗效果。然而，仍有很大比例的病例对这种治疗方法没有反应，导致因并发症而死亡。最近，一种新的非造血细胞来源——间充质干细胞（MSCs），具有重建免疫稳态和组织再生的潜力，已广泛应用于基础和临床研究。MSCs 的一个显著特征是其抗炎和免疫抑制特性以及刺激组织分化程序。在背景信号的影响下，MSCs 迁移到炎症生物活性物质，然后调节过度活跃的免疫反应以恢复免疫耐受。MSCs 与大多数免疫细胞之间表现出双向相互作用，这在解决无菌性炎症中起着重要作用。据报道，MSCs 可通过限制炎症细胞进入炎症部位和重新教育浸润细胞来实现耐受表型，从而实现组织修复。除了释放免疫调节药物外，刺激内源性和组织驻留的干细胞表明 MSC 移植作为未来免疫介导性疾病治疗的一种潜在方式。
