BMP4 信号在多能性向滋养层细胞的出现中的作用。
The role of BMP4 signaling in trophoblast emergence from pluripotency.
机构信息
Division of Animal Sciences and Bond Life Sciences Center, University of Missouri, Columbia, MO, USA.
Colorado Center for Reproductive Medicine, 10290 Ridgegate Circle, Lone Tree, CO, 80124, USA.
出版信息
Cell Mol Life Sci. 2022 Jul 25;79(8):447. doi: 10.1007/s00018-022-04478-w.
Abstract
The Bone Morphogenetic Protein (BMP) signaling pathway has established roles in early embryonic morphogenesis, particularly in the epiblast. More recently, however, it has also been implicated in development of extraembryonic lineages, including trophectoderm (TE), in both mouse and human. In this review, we will provide an overview of this signaling pathway, with a focus on BMP4, and its role in emergence and development of TE in both early mouse and human embryogenesis. Subsequently, we will build on these in vivo data and discuss the utility of BMP4-based protocols for in vitro conversion of primed vs. naïve pluripotent stem cells (PSC) into trophoblast, and specifically into trophoblast stem cells (TSC). PSC-derived TSC could provide an abundant, reproducible, and ethically acceptable source of cells for modeling placental development.
摘要
骨形态发生蛋白（BMP）信号通路在早期胚胎形态发生中具有重要作用，特别是在胚胎外胚层中。然而，最近它也被牵涉到胚胎外谱系的发育中，包括滋养外胚层（TE），在小鼠和人类中都是如此。在这篇综述中，我们将概述该信号通路，重点介绍 BMP4 及其在早期小鼠和人类胚胎发生中 TE 出现和发育中的作用。随后，我们将基于这些体内数据讨论基于 BMP4 的方案在体外将原始和幼稚多能干细胞（PSC）转化为滋养层，特别是转化为滋养层干细胞（TSC）的用途。PSC 衍生的 TSC 可以为胎盘发育的建模提供丰富、可重复和符合伦理的细胞来源。
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