Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Department of Pathology, Augusta University, Augusta, GA 30912, USA.
Curr Oncol. 2022 Jun 30;29(7):4625-4631. doi: 10.3390/curroncol29070367.
Chordoma is a rare malignant neoplasm derived from notochordal tissue that primarily affects the axial skeleton. Almost 40% of patients have non-cranial chordoma metastases. The most common metastatic sites are the lungs, bones, lymph nodes, and subcutaneous tissue. We present a 52-year female with a history of sacral chordoma presenting with abdominal fullness, early satiety, and a palpable abdominal mass. Abdominal magnetic resonance imaging (MRI) revealed an isolated, highly vascularized, and multilobed liver mass in the left lateral segment. The mass was surgically removed using a clean surgical margin. A histological examination and immunohistochemical staining were consistent with a metastatic chordoma. Two years later, follow-up imaging studies showed a 6.5 × 4.0 × 2.0 cm right liver lesion with multiple lungs, chest wall, pleural, and diaphragmatic lesions. Microscopic- and immunohistochemical staining revealed a recurrent metastatic chordoma. Herein, we present a unique case of metastatic recurrent chordoma in the liver with the involvement of other sites. To the best of our knowledge, no other case of recurrent liver metastasis has been reported.
脊索瘤是一种罕见的源自脊索组织的恶性肿瘤，主要影响轴性骨骼。近 40%的患者有颅外脊索瘤转移。最常见的转移部位是肺、骨骼、淋巴结和皮下组织。我们报告了一例 52 岁女性骶骨脊索瘤病史，表现为腹胀、早饱和可触及的腹部肿块。腹部磁共振成像（MRI）显示左外侧段有一个孤立的、富含血管的多叶肝肿块。该肿块通过清洁手术边缘切除。组织学检查和免疫组织化学染色与转移性脊索瘤一致。两年后，随访影像学研究显示右侧肝脏有一个 6.5×4.0×2.0 cm 的病变，伴有多个肺部、胸壁、胸膜和膈肌病变。显微镜和免疫组织化学染色显示复发性转移性脊索瘤。在此，我们报告了一例独特的肝转移复发性脊索瘤病例，伴其他部位受累。据我们所知，没有其他复发性肝转移的病例报告。
