Neurosurgery Unit, Department of Neurosciences, University of Modena and Reggio Emilia, University Hospital of Modena, Modena, Italy.
Neurosurgery Unit, Department of Neurosciences, University of Modena and Reggio Emilia, University Hospital of Modena, Modena, Italy.
World Neurosurg. 2020 May;137:296-303. doi: 10.1016/j.wneu.2020.02.018. Epub 2020 Feb 15.
Chordomas are rare primary tumors of the bone that arise from embryonic notochord. They are locally aggressive tumors with a high tendency for postsurgical recurrence. On the other hand, distant metastases are rare. When they occur, they involve lungs, liver, lymph nodes, and bones. Skin and subcutaneous tissue involvement is even rarer and usually occurs by direct extension of the primary tumor or by local recurrence. Distant cutaneous metastasis from chordoma is an exceptional finding, with fewer than 20 cases reported in the literature. All the cutaneous metastases described derive from sacral chordomas, except for 2 cases in which the source of metastasis is skull-base chordomas.
We report the case of a 55-year-old man with skin metastasis from a cervical chordoma.
Metastasis has to be taken into account in the differential diagnosis when a new skin lesion appears in a patient with a past medical history of chordoma. To the best of our knowledge, this is the first case of cutaneous metastasis from spinal cervical chordoma. A systematic literature review was performed.
脊索瘤是一种罕见的原发于骨骼的肿瘤，来源于胚胎脊索。它具有局部侵袭性，且术后复发率高。另一方面，远处转移较为罕见，转移部位通常为肺、肝、淋巴结和骨骼。皮肤和皮下组织受累更为罕见，通常由原发肿瘤的直接蔓延或局部复发引起。脊索瘤的远处皮肤转移极为罕见，文献中报道的病例不足 20 例。所有描述的皮肤转移均来源于骶尾部脊索瘤，仅 2 例的转移来源为颅底脊索瘤。
我们报告了一例 55 岁男性的颈段脊索瘤皮肤转移病例。
当患者既往有脊索瘤病史时，若出现新的皮肤病变，需要考虑转移的可能。据我们所知，这是首例颈段脊柱脊索瘤皮肤转移病例。我们进行了系统的文献回顾。
