Robertson R T
Neurosci Lett. 1987 Apr 10;75(3):259-64. doi: 10.1016/0304-3940(87)90531-3.
Experiments in infant rats have revealed patterns of intense acetylcholinesterase (AChE) activity in primary sensory thalamic nuclei and thalamocortical recipient zones of primary sensory areas of cerebral cortex. The distribution and appearance of AChE staining indicates that the transient AChE in these areas is characteristic of thalamocortical neurons. The patterns of AChE are detectable during the first postnatal week of life, reach peak intensity during the second postnatal week, and decline to normal adult levels by the end of the third postnatal week. These temporal parameters correlate well with the time of thalamocortical axon growth into the cerebral cortex. These data suggest that the transient AChE may be playing a morphogenic role in the development of thalamocortical connections.
对幼鼠进行的实验揭示了在初级感觉丘脑核以及大脑皮质初级感觉区的丘脑皮质接受区中存在强烈的乙酰胆碱酯酶（AChE）活性模式。AChE染色的分布和外观表明，这些区域中的短暂性AChE是丘脑皮质神经元的特征。AChE模式在出生后的第一周内可检测到，在出生后的第二周达到峰值强度，并在出生后的第三周结束时降至正常成年水平。这些时间参数与丘脑皮质轴突生长进入大脑皮质的时间密切相关。这些数据表明，短暂性AChE可能在丘脑皮质连接的发育中发挥形态发生作用。
