Howe Brian J, Pendleton Chandler, Withanage Miyuraj Harishchandra Hikkaduwa, Childs Christopher A, Zeng Erliang, van Wijk Arjen, Hermus Ruurd, Padilla Carmencita, Hecht Jacqueline T, Poletta Fernando A, Orioli Iêda M, Buxó-Martínez Carmen J, Deleyiannis Frederic, Vieira Alexandre R, Butali Azeez, Valencia-Ramirez Consuelo, Restrepo Muñeton Claudia, Wehby George L, Weinberg Seth M, Marazita Mary L, Moreno Uribe Lina M, Xie Xian-Jin
Department of Family Dentistry, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA.
The Iowa Institute for Oral Health Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA.
Dent J (Basel). 2022 Jul 5;10(7):128. doi: 10.3390/dj10070128.
Individuals with orofacial clefting (OFC) have a higher prevalence of tooth agenesis (TA) overall. Neither the precise etiology of TA, nor whether TA occurs in patterns that differ by gender or cleft type is yet known. This meta-analysis aims to identify the spectrum of tooth agenesis patterns in subjects with non-syndromic OFC and controls using the Tooth Agenesis Code (TAC) program. An indexed search of databases (PubMed, EMBASE, and CINAHL) along with cross-referencing and hand searches were completed from May to June 2019 and re-run in February 2022. Additionally, unpublished TAC data from 914 individuals with OFC and 932 controls were included. TAC pattern frequencies per study were analyzed using a random effects meta-analysis model. A thorough review of 45 records retrieved resulted in 4 articles meeting eligibility criteria, comprising 2182 subjects with OFC and 3171 controls. No TA (0.0.0.0) was seen in 51% of OFC cases and 97% of controls. TAC patterns 0.2.0.0, 2.0.0.0, and 2.2.0.0 indicating uni- or bi-lateral missing upper laterals, and 16.0.0.0 indicating missing upper right second premolar, were more common in subjects with OFC. Subjects with OFC have unique TA patterns and defining these patterns will help increase our understanding of the complex etiology underlying TA.
患有口面部裂隙（OFC）的个体总体上牙齿发育不全（TA）的患病率更高。目前尚不清楚TA的确切病因，也不清楚TA是否存在因性别或腭裂类型而异的模式。这项荟萃分析旨在使用牙齿发育不全编码（TAC）程序确定非综合征性OFC患者和对照组中牙齿发育不全模式的范围。2019年5月至6月完成了对数据库（PubMed、EMBASE和CINAHL）的索引搜索以及交叉引用和手工检索，并于2022年2月重新运行。此外，还纳入了来自914名OFC患者和932名对照的未发表的TAC数据。使用随机效应荟萃分析模型分析每项研究的TAC模式频率。对检索到的45条记录进行全面审查后，有4篇文章符合纳入标准，包括2182名OFC患者和3171名对照。51%的OFC病例和97%的对照中未发现TA（0.0.0.0）。TAC模式0.2.0.0、2.0.0.0和2.2.0.0表明单侧或双侧上颌侧切牙缺失，16.0.0.0表明右上颌第二前磨牙缺失，在OFC患者中更为常见。OFC患者有独特的TA模式，确定这些模式将有助于增进我们对TA潜在复杂病因的理解。
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