Falusi Fanni, Berkó Szilvia, Kovács Anita, Budai-Szűcs Mária
Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, Eötvös u. 6, 6720 Szeged, Hungary.
Gels. 2022 Jun 30;8(7):413. doi: 10.3390/gels8070413.
Foams are increasingly popular in the field of dermatology due to their many advantages such as easy spreading, good skin sensation, and applicability in special skin conditions. One of the critical points of foam formulation is the choice of the appropriate stabilizing ingredients. One of the stability-increasing strategies is retarding the liquid drainage of liquid films from the foam structure. Therefore, our aim was the application of different hydrogel-forming polymers in order to retain the stabilizing liquid film. Dexpanthenol and niacinamide-containing foams were formulated, where xanthan gum and hyaluronic acid were used as foam-stabilizing polymers. Amplitude (LVE range) and frequency sweep (G', G", tanδ, and frequency dependency) were applied as structure- and stability-indicating rheological parameters. The rheological data were compared with the results of the cylinder method, microscopical images, and the spreadability measurements. The application of the gel-forming polymers increased the stability of the dermal foams (increased LVE range, G' values, and decreased frequency dependency). These results were in correlation with the results of the cylinder and spreadability tests. It was concluded that in terms of both foam formation and stability, the combination of xanthan gum and dexpanthenol can be ideal.
由于具有易于铺展、良好的皮肤感觉以及适用于特殊皮肤状况等诸多优点，泡沫在皮肤科领域越来越受欢迎。泡沫制剂的关键要点之一是选择合适的稳定成分。增加稳定性的策略之一是延缓液膜从泡沫结构中的液体排出。因此，我们的目标是应用不同的形成水凝胶的聚合物来保留稳定的液膜。制备了含泛醇和烟酰胺的泡沫，其中黄原胶和透明质酸用作泡沫稳定聚合物。应用振幅（线性粘弹性范围）和频率扫描（储能模量G'、损耗模量G"、损耗因子tanδ和频率依赖性）作为指示结构和稳定性的流变学参数。将流变学数据与圆筒法、显微镜图像和铺展性测量结果进行比较。形成凝胶的聚合物的应用提高了皮肤泡沫的稳定性（增加了线性粘弹性范围、G'值并降低了频率依赖性）。这些结果与圆筒法和铺展性测试的结果相关。得出的结论是，就泡沫形成和稳定性而言，黄原胶和泛醇的组合可能是理想的。
