Božič Mijovski Mojca, Antovic Jovan P, Malmström Rickard E, Mavri Alenka
Department of Vascular Diseases, University Medical Centre Ljubljana, 1000 Ljubljana, Slovenia.
Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia.
J Cardiovasc Dev Dis. 2022 Jun 29;9(7):205. doi: 10.3390/jcdd9070205.
Rotational thromboelastometry (ROTEM) is a viscoelastic hemostasis test used primarily in the management of bleeding after trauma or in cardiac surgery. To allow safe and valid clinical interpretation of test results, objective specifications for analytical performance are needed, which are generally based on biological variation within (CV) and between (CV) individuals. The aim of this study was to evaluate biological variation in ROTEM in patients receiving rivaroxaban. Sixty patients with atrial fibrillation on stable rivaroxaban therapy were included, from whom blood was collected on six occasions: three times at trough and three at peak rivaroxaban concentrations. ROTEM Extem and LowTF were measured as well as rivaroxaban concentration, PT, APTT, and anti-Xa. Within- (CV) and between-subject (CV) biological estimates were calculated. Knowledge of these biological variation components will help to establish the appropriate objective analytical performance specifications for ROTEM analysis.
旋转血栓弹力图（ROTEM）是一种粘弹性止血测试，主要用于创伤后出血管理或心脏手术。为了对测试结果进行安全有效的临床解读，需要基于个体内（CV）和个体间（CV）的生物学变异制定分析性能的客观规范。本研究的目的是评估接受利伐沙班治疗的患者中ROTEM的生物学变异。纳入了60例接受稳定利伐沙班治疗的房颤患者，在六个时间点采集血液：利伐沙班浓度处于谷值时三次，处于峰值时三次。测量了ROTEM Extem和LowTF以及利伐沙班浓度、PT、APTT和抗Xa。计算了个体内（CV）和个体间（CV）的生物学估计值。了解这些生物学变异成分将有助于为ROTEM分析建立适当的客观分析性能规范。
