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大鼠后间隔或缰核的损伤会降低(通过放射自显影测量)大鼠脚间核中[³H]半胆碱-3的结合。

Lesions of the posterior septum or of the habenula decrease [3H]hemicholinium-3 binding (as measured by autoradiography) in the interpeduncular nucleus of the rat.

作者信息

Motohashi N, Dubois A, Scatton B

出版信息

Neurosci Lett. 1987 May 19;76(3):339-44. doi: 10.1016/0304-3940(87)90426-5.

DOI:10.1016/0304-3940(87)90426-5
PMID:3587764
Abstract

The effects of a bilateral electrolytic lesion of the posterior septum or of the habenula (lateral and medial parts) on [3H]hemicholinium-3 binding sites in the interpeduncular nucleus of the rat were studied through the use of quantitative autoradiography. Lesions of the habenular nuclei or of the posterior septum decreased [3H]hemicholinium-3 binding in the interpeduncular nucleus by 93 and 31%, respectively. These results add further support to the view that the habenula and posterior septum are the major sources of the cholinergic innervation of the interpeduncular nucleus in the rat.

摘要

通过定量放射自显影术,研究了双侧电解损伤后隔或缰核(外侧和内侧部分)对大鼠脚间核中[3H]半胱氨酸-3结合位点的影响。缰核或后隔损伤分别使脚间核中[3H]半胱氨酸-3结合减少93%和31%。这些结果进一步支持了以下观点:缰核和后隔是大鼠脚间核胆碱能神经支配的主要来源。

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