Villani L, Battistini S, Bissoli R, Contestabile A
Neurosci Lett. 1987 May 19;76(3):263-8. doi: 10.1016/0304-3940(87)90412-5.
Experiments were performed in order to see whether acetylcholine is a neurotransmitter in the telencephalo-habenulo-interpeduncular system of the goldfish. After telencephalic ablation choline acetyltransferase decreased by 53% in the habenular nuclei but was unchanged in the interpeduncular nucleus. After combined telencephalic and habenular lesions, the enzyme level dropped by 95% in the interpeduncular nucleus. These results suggest the existence of a telencephalo-habenular and a habenulo-interpeduncular cholinergic projection in the goldfish, as previously demonstrated in mammals. Acetylcholinesterase histochemistry additionally demonstrates some similarities between the habenulae and the interpeduncular nucleus in the goldfish and in mammals.
为了确定乙酰胆碱是否为金鱼端脑-缰核-脚间核系统中的神经递质，进行了相关实验。端脑切除后，缰核中胆碱乙酰转移酶减少了53%，但脚间核中的该酶水平未发生变化。端脑和缰核联合损伤后，脚间核中的酶水平下降了95%。这些结果表明，金鱼中存在端脑-缰核和缰核-脚间核胆碱能投射，正如之前在哺乳动物中所证实的那样。乙酰胆碱酯酶组织化学进一步证明了金鱼和哺乳动物的缰核与脚间核之间存在一些相似之处。
