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使用中空纤维膜研究透析治疗：一种基于计算流体动力学的新方法。

Investigating the Dialysis Treatment Using Hollow Fiber Membrane: A New Approach by CFD.

作者信息

Magalhães Hortência L F, Gomez Ricardo S, Leite Boniek E, Nascimento Jéssica B S, Brito Mirenia K T, Araújo Morgana V, Cavalcante Daniel C M, Lima Elisiane S, Lima Antonio G B, Farias Neto Severino R

机构信息

Department of Chemical Engineering, Federal University of Campina Grande, Campina Grande 58429-900, Brazil.

Department of Mechanical Engineering, Federal University of Campina Grande, Campina Grande 58429-900, Brazil.

出版信息

Membranes (Basel). 2022 Jul 15;12(7):710. doi: 10.3390/membranes12070710.

DOI:10.3390/membranes12070710
PMID:35877913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9320344/
Abstract

Due to the increase in the number of people affected by chronic renal failure, the demand for hemodialysis treatment has increased considerably over the years. In this sense, theoretical and experimental studies to improve the equipment (hemodialyzer) are extremely important, due to their potential impact on the patient's life quality undergoing treatment. To contribute to this research line, this work aims to study the fluid behavior inside a hollow fiber dialyzer using computational fluid dynamics. In that new approach, the blood is considered as multiphase fluid and the membrane as an extra flow resistance in the porous region (momentum sink). The numerical study of the hemodialysis process was based on the development of a mathematical model that allowed analyzing the performance of the system using Ansys Fluent software. The predicted results were compared with results reported in the literature and a good concordance was obtained. The simulation results showed that the proposed model can predict the fluid behavior inside the hollow fiber membrane adequately. In addition, it was found that the clearance decreases with increasing radial viscous resistance, with greater permeations in the vicinity of the lumen inlet region, as well as the emergence of the retrofiltration phenomenon, characteristic of this type of process. Herein, velocity, pressure, and volumetric fraction fields are presented and analyzed.

摘要

由于受慢性肾衰竭影响的人数不断增加，多年来血液透析治疗的需求大幅增长。从这个意义上讲，旨在改进设备（血液透析器）的理论和实验研究极其重要，因为它们对接受治疗的患者生活质量具有潜在影响。为推动这一研究方向，本工作旨在使用计算流体动力学研究中空纤维透析器内部的流体行为。在这种新方法中，血液被视为多相流体，而膜被视为多孔区域中的额外流动阻力（动量汇）。血液透析过程的数值研究基于一个数学模型的开发，该模型允许使用Ansys Fluent软件分析系统性能。将预测结果与文献报道的结果进行比较，获得了良好的一致性。模拟结果表明，所提出的模型能够充分预测中空纤维膜内部的流体行为。此外，还发现清除率随着径向粘性阻力的增加而降低，在管腔入口区域附近具有更大的渗透，以及出现了这种类型过程特有的反滤过现象。在此展示并分析了速度、压力和体积分数场。

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本文引用的文献

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2
Brazilian Chronic Dialysis Survey 2016.2016年巴西慢性透析调查
J Bras Nefrol. 2017 Jul-Sep;39(3):261-266. doi: 10.5935/0101-2800.20170049.
3
Solute Transport in Hemodialysis: Advances and Limitations of Current Membrane Technology.血液透析中的溶质转运：当前膜技术的进展与局限
基于计算流体动力学-离散单元法（CFD-DEM）对滚动摩擦系数对木质素颗粒在单个陶瓷膜孔内沉积影响的研究。
Membranes (Basel). 2023 Mar 27;13(4):382. doi: 10.3390/membranes13040382.
Contrib Nephrol. 2017;191:84-99. doi: 10.1159/000479258. Epub 2017 Sep 14.
4
Three-dimensional simulation of mass transfer in artificial kidneys.人工肾中传质的三维模拟
Artif Organs. 2015 Jun;39(6):E79-89. doi: 10.1111/aor.12415. Epub 2015 Mar 3.
5
Effects of dialysate flow configurations in continuous renal replacement therapy on solute removal: computational modeling.连续肾脏替代治疗中透析液流动方式对溶质清除的影响：计算模型。
Blood Purif. 2013;35(1-3):106-11. doi: 10.1159/000346093. Epub 2013 Jan 22.
6
Intracapsular hip fractures in end-stage renal failure.终末期肾衰竭患者的囊内髋部骨折
Injury. 2006 Feb;37(2):175-84. doi: 10.1016/j.injury.2005.11.006. Epub 2006 Jan 19.
7
A numerical and experimental study of mass transfer in the artificial kidney.人工肾中传质的数值与实验研究。
J Biomech Eng. 2003 Aug;125(4):472-80. doi: 10.1115/1.1589776.
8
Review on uremic toxins: classification, concentration, and interindividual variability.尿毒症毒素综述：分类、浓度及个体间变异性
Kidney Int. 2003 May;63(5):1934-43. doi: 10.1046/j.1523-1755.2003.00924.x.