Chang Chia-Hau, Chen Shih-Hsuan, Liu Peng-Huei, Huang Kuo-Chen, Chiu I-Min, Pan Hsiu-Yung, Cheng Fu-Jen
Department of Emergency Medicine, New Taipei Municipal Tucheng Hospital, New Taipei 236, Taiwan.
Department of Emergency Medicine, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Toxics. 2022 Jun 25;10(7):350. doi: 10.3390/toxics10070350.
Stroke is a leading cause of death, and air pollution is associated with stroke hospitalization. However, the susceptibility factors are unclear. Retrospective studies from 2014 to 2018 in Kaohsiung, Taiwan, were analyzed. Adult patients (>17 years) admitted to a medical center with stroke diagnosis were enrolled and patient characteristics and comorbidities were recorded. Air pollutant measurements, including those of particulate matter (PM) with aerodynamic diameters < 10 μm (PM10) and < 2.5 μm (PM2.5), nitrogen dioxide (NO2), and ozone (O3), were collected from air quality monitoring stations. During the study period, interquartile range (IQR) increments in PM2.5 on lag3 and lag4 were 12.3% (95% CI, 1.1−24.7%) and 11.5% (95% CI, 0.3−23.9%) concerning the risk of stroke hospitalization, respectively. Subgroup analysis revealed that the risk of stroke hospitalization after exposure to PM2.5 was greater for those with advanced age (≥80 years, interaction p = 0.045) and hypertension (interaction p = 0.034), after adjusting for temperature and humidity. A dose-dependent effect of PM2.5 on stroke hospitalization was evident. This is one of few studies focusing on the health effects of PM2.5 for patients with risk factors of stroke. We found that patients with risk factors, such as advanced age and hypertension, are more susceptible to PM2.5 impacts on stroke hospitalization.
中风是主要的死亡原因之一，空气污染与中风住院相关。然而，易感因素尚不清楚。对台湾高雄2014年至2018年的回顾性研究进行了分析。纳入了入住某医疗中心且诊断为中风的成年患者（>17岁），记录患者特征和合并症。从空气质量监测站收集空气污染物测量数据，包括空气动力学直径<10μm（PM10）和<2.5μm（PM2.5）的颗粒物、二氧化氮（NO2）和臭氧（O3）。在研究期间，就中风住院风险而言，滞后3天和滞后4天的PM2.5四分位数间距（IQR）增量分别为12.3%（95%CI，1.1−24.%-7%）和11.5%（95%CI，0.3−23.9%）。亚组分析显示，在调整温度和湿度后，高龄（≥80岁，交互作用p=0.045）和高血压患者（交互作用p=0.034）暴露于PM2.5后中风住院风险更高。PM2.5对中风住院存在剂量依赖效应。这是为数不多的关注PM2.5对中风危险因素患者健康影响的研究之一。我们发现，高龄和高血压等有危险因素的患者更容易受到PM2.5对中风住院影响。
