Huang Kuo-Chen, Pan Hsiu-Yung, Hsieh Ting-Min, Chen Chih-Cheng, Cheng Fu-Jen
Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Dapi Road, Niaosong Township, Kaohsiung County 833, Kaohsiung City, Taiwan.
Division of Trauma, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City, Taiwan.
BMC Public Health. 2025 Jan 24;25(1):306. doi: 10.1186/s12889-025-21517-w.
Asthma is a common respiratory disease in children, and air pollution is a risk factor for pediatric asthma. However, how air pollution affects blood cells in pediatric patients with asthma remains unclear.
This retrospective observational study, performed in 2007-2018 at a medical center, enrolled non-trauma patients aged < 17 years who visited the emergency department and had asthma. Medical records and blood cell counts, including absolute neutrophil count (ANC), eosinophil count, and platelet count were extracted. The concentrations of PM, PM, sulfur dioxide (SO), nitrogen dioxide (NO), and ozone (O) were measured from 11 air-monitoring stations in Kaohsiung City.
One-unit increases in PM (regression coefficient: 25.618; S.E.: 5.937; p < 0.001), PM (19.97; 3.541; p < 0.001), NO2 (70.681; 15.857; p < 0.001), SO (81.694; 30.339; p = 0.007), and O (23.42; 8.831; p = 0.022) on lag 0-6 (7 d average) correlated positively with ANC. One-unit increases in PM (0.859; 0.357; p = 0.016), PM (0.728; 0.213; p = 0.001), and SO (4.086; 1.811; p = 0.024) on lag 0-6 correlated positively with eosinophil count. Additionally, one-unit increases in PM (0.302; 0.101; p = 0.003) and PM (0.229; 0.06; p < 0.001) on lag 0-6 correlated positively with platelet count. In a two-pollutant model, the impacts of PM and PM on ANC and platelet count remained statistically significant after adjusting for other air pollutants. Additionally, PM correlated significantly with eosinophil count after adjusting for PM, NO, SO, and O. Quartile increases in PM and PM levels correlated positively with ANC, eosinophil count, and platelet count (all p for trend < 0.05).
PM, PM, and NO were independently and positively associated with ANC, PM was positively associated with eosinophil count, and PM and PM were positively associated with platelet count in pediatric patients with asthma. Our results highlight the relationship between air pollution and blood cell counts in pediatric patients with asthma.
哮喘是儿童常见的呼吸道疾病，空气污染是儿童哮喘的一个危险因素。然而，空气污染如何影响哮喘患儿的血细胞仍不清楚。
这项回顾性观察研究于2007年至2018年在一家医疗中心进行，纳入了年龄小于17岁、因哮喘到急诊科就诊的非创伤患者。提取病历和血细胞计数，包括绝对中性粒细胞计数（ANC）、嗜酸性粒细胞计数和血小板计数。从高雄市11个空气监测站测量了PM、PM、二氧化硫（SO）、二氧化氮（NO）和臭氧（O）的浓度。
在滞后0 - 6天（7天平均值）时，PM（回归系数：25.618；标准误：5.937；p < 0.001）、PM（19.97；3.541；p < 0.001）、NO2（70.681；15.857；p < 0.001）、SO（81.694；30.339；p = 0.007）和O（23.42；8.831；p = 0.022）每增加一个单位与ANC呈正相关。在滞后0 - 6天，PM（0.859；0.357；p = 0.016）、PM（0.728；0.213；p = 0.001）和SO（4.086；1.811；p = 0.024）每增加一个单位与嗜酸性粒细胞计数呈正相关。此外，在滞后0 - 6天，PM（0.302；0.101；p = 0.003）和PM（0.229；0.06；p < 0.001）每增加一个单位与血小板计数呈正相关。在双污染物模型中，在调整其他空气污染物后，PM和PM对ANC和血小板计数的影响仍具有统计学意义。此外，在调整PM、NO、SO和O后，PM与嗜酸性粒细胞计数显著相关。PM和PM水平的四分位数增加与ANC、嗜酸性粒细胞计数和血小板计数呈正相关（所有趋势p < 0.05）。
在哮喘患儿中，PM、PM和NO与ANC独立正相关，PM与嗜酸性粒细胞计数正相关，PM和PM与血小板计数正相关。我们的结果突出了空气污染与哮喘患儿血细胞计数之间的关系。
