Wolter J R
Ophthalmic Paediatr Genet. 1987 Mar;8(1):35-42. doi: 10.3109/13816818709028513.
The influence of the very limited potential for an increase of blood supply to the inner eye on the growth of intraocular retinoblastoma are listed, demonstrated, and discussed. It is typical for the most malignant retinoblastomas to present with the most massive ischemia and necrosis. The limited possibilities for vascular enlargement and neovascularization lead to cuff-like perivascular survival of neoplastic cells with necrosis in the interspaces. Indirect supply from retinal and ciliary sources explain layer-like neoplastic growth on surface and base of tumors as well as separation of living neoplastic cells, attraction towards exit areas, cyst formation, and seeding. These processes may contribute to extraocular extension. Recognition of the limits of intraocular nutrition also is important for prognosis and therapy in cases of retinoblastoma.
列出、展示并讨论了眼内血液供应增加潜力非常有限对眼内视网膜母细胞瘤生长的影响。最恶性的视网膜母细胞瘤通常表现为最严重的缺血和坏死。血管扩张和新生血管形成的可能性有限，导致肿瘤细胞在血管周围呈袖状存活，间隙出现坏死。来自视网膜和睫状体来源的间接供应解释了肿瘤表面和底部的层状肿瘤生长，以及存活肿瘤细胞的分离、向出口区域的吸引、囊肿形成和播散。这些过程可能导致肿瘤眼外扩展。认识到眼内营养的局限性对于视网膜母细胞瘤病例的预后和治疗也很重要。
