Minoda K, Hirose Y, Sugano I, Nagao K, Kitahara K
Department of Ophthalmology, Teikyo University Ichihara Hospital, Japan.
Jpn J Ophthalmol. 1993;37(3):293-300.
A 13-year-old boy, whose bilateral retinoblastoma had been treated by enucleation (OD) and irradiation (OS), developed anterior staphyloma (OS) necessitating the second enucleation. Histopathological, immunohistochemical and electron microscopic studies revealed malignant teratoid medulloepithelioma of the ciliary body, with demonstrated multipotential histogenesis. This is the first report which demonstrates the development of a second malignant intraocular tumor in an eye previously affected by hereditary retinoblastoma. Careful monitoring of patients who have had hereditary retinoblastoma is necessary because of the potential for a second malignancy.
一名13岁男孩，其双侧视网膜母细胞瘤已通过眼球摘除术（右眼）和放射治疗（左眼）进行治疗，后来左眼出现前葡萄肿，需要进行第二次眼球摘除术。组织病理学、免疫组织化学和电子显微镜研究显示睫状体存在恶性畸胎样髓上皮瘤，证实了其多潜能组织发生。这是第一份报告，证明在先前受遗传性视网膜母细胞瘤影响的眼睛中发生了第二种恶性眼内肿瘤。由于存在发生第二种恶性肿瘤的可能性，对患有遗传性视网膜母细胞瘤的患者进行仔细监测是必要的。
