Wharam M, Beltangady M, Hays D, Heyn R, Ragab A, Soule E, Tefft M, Maurer H
Ophthalmology. 1987 Mar;94(3):251-4.
Children with rhabdomyosarcoma (RMS) (1461 total cases) were included in two prospective, randomized protocols conducted by the Intergroup Rhabdomyosarcoma Study (IRS) Committee from November 1972 to June 1983. Treatment assignment was determined by extent of tumor at diagnosis (clinicopathologic group) and not by primary site. Accordingly, 127 patients with RMS confined to the region of the eyelid and orbit were treated by a variety of regimens characterized by initial partial tumor resection followed by concurrent multiagent chemotherapy and orbital radiation therapy. Recurrent tumor developed in ten patients. Seven relapsed initially in the orbit (of whom 4 were salvaged) and three in regional nodes. In addition to the six patients who died of tumor, three died of other causes for a 93% 3-year actuarial survival rate. In 89 children who had subtotal resection or biopsy only, the local control rate with radiotherapy and chemotherapy was 94%.
1972年11月至1983年6月期间，横纹肌肉瘤（RMS）患儿（共1461例）被纳入横纹肌肉瘤协作组（IRS）委员会开展的两项前瞻性随机试验方案。治疗方案的分配取决于诊断时肿瘤的范围（临床病理组），而非原发部位。因此，127例局限于眼睑和眼眶区域的RMS患者接受了多种治疗方案，其特点是先进行肿瘤部分切除，随后进行联合多药化疗和眼眶放射治疗。10例患者出现肿瘤复发。7例最初在眼眶复发（其中4例得到挽救），3例在区域淋巴结复发。除6例死于肿瘤外，3例死于其他原因，3年实际生存率为93%。在仅接受次全切除或活检的89例儿童中，放疗和化疗后的局部控制率为94%。
