Tanriverdi Büşra, Gregory David F, Olino Thomas M, Ely Timothy D, Harnett Nathaniel G, van Rooij Sanne J H, Lebois Lauren A M, Seligowski Antonia V, Jovanovic Tanja, Ressler Kerry J, House Stacey L, Beaudoin Francesca L, An Xinming, Neylan Thomas C, Clifford Gari D, Linnstaedt Sarah D, Germine Laura T, Bollen Kenneth A, Rauch Scott L, Haran John P, Storrow Alan B, Lewandowski Christopher, Musey Paul I, Hendry Phyllis L, Sheikh Sophia, Jones Christopher W, Punches Brittany E, Kurz Michael C, McGrath Meghan E, Hudak Lauren A, Pascual Jose L, Seamon Mark J, Datner Elizabeth M, Pearson Claire, Domeier Robert M, Rathlev Niels K, O'Neil Brian J, Sanchez Leon D, Bruce Steven E, Miller Mark W, Pietrzak Robert H, Joormann Jutta, Barch Deanna M, Pizzagalli Diego A, Sheridan John F, Smoller Jordan W, Harte Steven E, Elliott James M, McLean Samuel A, Kessler Ronald C, Koenen Karestan C, Stevens Jennifer S, Murty Vishnu P
Department of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania 19121.
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329.
J Neurosci. 2022 Aug 24;42(34):6593-6604. doi: 10.1523/JNEUROSCI.0911-21.2022.
Hippo campal impairments are reliably associated with post-traumatic stress disorder (PTSD); however, little research has characterized how increased threat sensitivity may interact with arousal responses to alter hippocampal reactivity, and further how these interactions relate to the sequelae of trauma-related symptoms. In a sample of individuals recently exposed to trauma ( = 116, 76 female), we found that PTSD symptoms at 2 weeks were associated with decreased hippocampal responses to threat as assessed with fMRI. Further, the relationship between hippocampal threat sensitivity and PTSD symptomology only emerged in individuals who showed transient, high threat-related arousal, as assayed by an independently collected measure of fear potentiated startle. Collectively, our finding suggests that development of PTSD is associated with threat-related decreases in hippocampal function because of increases in fear-potentiated arousal. Alterations in hippocampal function linked to threat-related arousal are reliably associated with post-traumatic stress disorder (PTSD); however, how these alterations relate to the sequelae of trauma-related symptoms is unknown. Prior models based on nontrauma samples suggest that arousal may impact hippocampal neurophysiology leading to maladaptive behavior. Here we show that decreased hippocampal threat sensitivity interacts with fear-potentiated startle to predict PTSD symptoms. Specifically, individuals with high fear-potentiated startle and low, transient hippocampal threat sensitivity showed the greatest PTSD symptomology. These findings bridge literatures of threat-related arousal and hippocampal function to better understand PTSD risk.
海马体损伤与创伤后应激障碍（PTSD）密切相关；然而，很少有研究描述增加的威胁敏感性如何与唤醒反应相互作用以改变海马体反应性，以及这些相互作用如何与创伤相关症状的后遗症相关。在一个近期遭受创伤的个体样本（n = 116，76名女性）中，我们发现，通过功能磁共振成像（fMRI）评估，2周时的PTSD症状与海马体对威胁的反应降低有关。此外，海马体威胁敏感性与PTSD症状之间的关系仅在那些表现出短暂的、与威胁相关的高唤醒的个体中出现，这是通过独立收集的恐惧增强惊吓测量来测定的。总体而言，我们的研究结果表明，PTSD的发展与恐惧增强唤醒增加导致的海马体功能与威胁相关的降低有关。与威胁相关的唤醒相关的海马体功能改变与创伤后应激障碍（PTSD）密切相关；然而，这些改变如何与创伤相关症状的后遗症相关尚不清楚。基于非创伤样本的先前模型表明，唤醒可能影响海马体神经生理学，导致适应不良行为。在这里，我们表明海马体威胁敏感性降低与恐惧增强惊吓相互作用以预测PTSD症状。具体而言，恐惧增强惊吓高且海马体威胁敏感性低且短暂的个体表现出最严重的PTSD症状。这些发现架起了与威胁相关的唤醒和海马体功能的文献之间的桥梁，以更好地理解PTSD风险。
