淋巴管通透性。
Lymphatic Vascular Permeability.
机构信息
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, USA.
出版信息
Cold Spring Harb Perspect Med. 2022 Aug 15;12(8):a041274. doi: 10.1101/cshperspect.a041274.
Blood vessels have a regulated permeability to fluid and solutes, which allows for the delivery of nutrients and signaling molecules to all cells in the body, a process essential to life. The lymphatic vasculature is the second network of vessels in the body, making up part of the immune system, yet is not typically thought of as having a permeability to fluid and solute. However, the major function of the lymphatic vasculature is to regulate tissue fluid balance to prevent edema, so lymphatic vessels must be permeable to absorb and transport fluid efficiently. Only recently were lymphatic vessels discovered to be permeable, which has had many functional implications. In this review, we will provide an overview of what is known about lymphatic vascular permeability, discuss the biophysical and signaling mechanisms regulating lymphatic permeability, and examine the disease relevance of this new property of lymphatic vessels.
血管对液体和溶质具有调节通透性，这使得营养物质和信号分子能够输送到体内所有细胞，这是生命所必需的过程。淋巴管系统是人体的第二个血管网络，构成免疫系统的一部分，但通常不被认为具有对液体和溶质的通透性。然而，淋巴管系统的主要功能是调节组织液平衡以防止水肿，因此淋巴管必须具有通透性以有效地吸收和运输液体。直到最近才发现淋巴管具有通透性，这具有许多功能意义。在这篇综述中，我们将概述已知的关于淋巴管通透性的知识，讨论调节淋巴管通透性的生物物理和信号机制，并研究淋巴管这一新特性与疾病的相关性。
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