ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 20031, China; Shanghai clinical medical center of hearing medicine, Shanghai 200031, China; Otology and Neurotology of Miller School of Medicine, Miami University, 9375 SW 77th Avenue, #1019, 33156 Miami, USA.
ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China; NHC Key Laboratory of Hearing Medicine, Fudan University, Shanghai 20031, China; Shanghai clinical medical center of hearing medicine, Shanghai 200031, China.
Auris Nasus Larynx. 2023 Apr;50(2):228-234. doi: 10.1016/j.anl.2022.07.003. Epub 2022 Jul 22.
To evaluate the effects of DX and HA on hearing preservation and tissue response with cochlear implantation in a cat mode.
11 cats were bilaterally implanted with Nurotron electrode. According to the different treatment, 22 ears were subdivided into four following groups: Electrode (E) only, Electrode +HA (E+H), Electrode + DX (E+DX), and Electrode +HA +DX (E+H+DX). Auditory brainstem responses (ABR) thresholds were recorded before and 3 months after surgery. After 3 months of cochlear implantation histopathological assessment of all cochleae were performed .
At low frequencies, the mean ABR thresholds shift in animals treated with E+H+DX demonstrated a statistically significant difference. The proportion of cochleae showing fibrous tissue and new bone formation was 50% in E+H+DX group, 66.7% in E+DX group, 83.3% in E+H group and 100% in E group.
United HA and DX local delivery could provide better protection against hearing loss at low-frequency threshold and could more effectively reduce the trauma related to electrode insertion and the fibrous tissue formation around the electrode.
评估 DX 和 HA 对猫模型中耳蜗植入后听力保护和组织反应的影响。
将 11 只猫双侧植入 Nurotron 电极。根据不同的处理方式，将 22 只耳朵分为以下四组：仅电极（E）、电极+HA（E+H）、电极+DX（E+DX）和电极+HA+DX（E+H+DX）。在手术前和术后 3 个月记录听觉脑干反应（ABR）阈值。在耳蜗植入后 3 个月，对所有耳蜗进行组织病理学评估。
在低频时，联合使用 E+H+DX 的动物的平均 ABR 阈值变化有统计学意义。E+H+DX 组中出现纤维组织和新骨形成的耳蜗比例为 50%，E+DX 组为 66.7%，E+H 组为 83.3%，E 组为 100%。
联合 HA 和 DX 局部给药可以更好地保护低频阈值的听力损失，并可以更有效地减少电极插入引起的创伤和电极周围纤维组织的形成。
