Division of Cancer Immunology, Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC), National Cancer Center, Tokyo, Japan.
Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Eur J Immunol. 2022 Aug;52(8):1216-1227. doi: 10.1002/eji.202149358. Epub 2022 Jul 25.
Regulatory T (Treg) cells are required for maintaining self-tolerance and preventing the development of autoimmune diseases. However, Treg cells are abundant in tumors and suppress antitumor immunity, contributing to tumor development and growth. Thus, the selective deletion of tumor-infiltrating Treg cells is important for successful Treg cell-targeted therapies, providing effective antitumor immunity without inducing deleterious autoimmune disorders. Advancements in sequencing technologies have exposed the diversity and heterogeneity of human Treg cells during activation and differentiation, further emphasizing the importance of understanding tumor-infiltrating Treg cells for the development of Treg cell-targeted therapies. This review provides an overview of the classification and function of Treg cells and summarizes recent knowledge on the activation and differentiation of Treg cells in the tumor microenvironment.
调节性 T（Treg）细胞对于维持自身耐受和防止自身免疫性疾病的发展是必需的。然而，Treg 细胞在肿瘤中大量存在，并抑制抗肿瘤免疫，促进肿瘤的发生和生长。因此，选择性地删除肿瘤浸润性 Treg 细胞对于成功的 Treg 细胞靶向治疗非常重要，它可以提供有效的抗肿瘤免疫，而不会引起有害的自身免疫性疾病。测序技术的进步揭示了人类 Treg 细胞在激活和分化过程中的多样性和异质性，进一步强调了了解肿瘤浸润性 Treg 细胞对于开发 Treg 细胞靶向治疗的重要性。本综述概述了 Treg 细胞的分类和功能，并总结了最近关于 Treg 细胞在肿瘤微环境中的激活和分化的知识。
