Department of Life Science, Sogang University, 35 Baekbeom-ro, Mapo-gu, Seoul 04107, Republic of Korea.
Mediators Inflamm. 2017;2017:5458178. doi: 10.1155/2017/5458178. Epub 2017 Dec 31.
Regulatory T (Treg) cells maintain immune homeostasis by suppressing excessive immune responses. Treg cells induce tolerance against self- and foreign antigens, thus preventing autoimmunity, allergy, graft rejection, and fetus rejection during pregnancy. However, Treg cells also infiltrate into tumors and inhibit antitumor immune responses, thus inhibiting anticancer therapy. Depleting whole Treg cell populations in the body to enhance anticancer treatments will produce deleterious autoimmune diseases. Therefore, understanding the precise nature of tumor-infiltrating Treg cells is essential for effectively targeting Treg cells in tumors. This review summarizes recent results relating to Treg cells in the tumor microenvironment, with particular emphasis on their accumulation, phenotypic, and functional properties, and targeting to enhance the efficacy of anticancer treatment.
调节性 T（Treg）细胞通过抑制过度的免疫反应来维持免疫稳态。Treg 细胞诱导对自身和外来抗原的耐受性，从而防止自身免疫、过敏、移植物排斥和怀孕期间的胎儿排斥。然而，Treg 细胞也浸润到肿瘤中，并抑制抗肿瘤免疫反应，从而抑制抗癌治疗。耗尽体内的全 Treg 细胞群以增强抗癌治疗会产生有害的自身免疫性疾病。因此，了解肿瘤浸润性 Treg 细胞的精确性质对于有效地靶向肿瘤中的 Treg 细胞至关重要。本综述总结了与肿瘤微环境中的 Treg 细胞有关的最新结果，特别强调了它们的积累、表型和功能特性，以及靶向以增强抗癌治疗的疗效。
