儿童非母乳喂养与自闭症谱系障碍风险：一项荟萃分析
Not breastfeeding and risk of autism spectrum disorders among children: a meta-analysis.
作者信息
Jenabi Ensiyeh, Bashirian Saeid, Salehi Amir Mohammad, Khazaei Salman
机构信息
Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Clin Exp Pediatr. 2023 Jan;66(1):28-31. doi: 10.3345/cep.2021.01872. Epub 2022 Jul 19.
BACKGROUND
To our knowledge, this is the first meta-analysis of the association of not breastfeeding and the risk of autism spectrum disorder (ASD) based on observational studies.
PURPOSE
This meta-analysis aimed to evaluate of the association of not breastfeeding and the risk of ASD.
METHODS
Three databases (PubMed, Web of Science, and Scopus) were systematically searched until December 2021. Heterogeneity was determined using the chi-square test and its quantity was measured using the I2 statistic. The Begg line regression test was used to assess publication bias. A random-effects model was used to analyze the data. Seven studies were included in this meta-analysis.
RESULTS
The total study population included 3,270 individuals. According to the random-effects model, the estimated odds ratio of the risk of ASD associated with not breastfeeding was 1.81 (95% confidence interval, 1.35-2.27; I2=0%).
CONCLUSION
The results of the included studies were homogeneous. Our findings showed that not breastfeeding is a risk factor for ASD. These results suggest the importance of breastfeeding in decreasing the risk of ASD in children.
背景
据我们所知，这是基于观察性研究对未进行母乳喂养与自闭症谱系障碍（ASD）风险之间关联的首次荟萃分析。
目的
本荟萃分析旨在评估未进行母乳喂养与ASD风险之间的关联。
方法
系统检索了三个数据库（PubMed、科学网和Scopus）直至2021年12月。使用卡方检验确定异质性，并使用I²统计量测量其大小。采用Begg线性回归检验评估发表偏倚。使用随机效应模型分析数据。本荟萃分析纳入了七项研究。
结果
研究总人群包括3270名个体。根据随机效应模型，未进行母乳喂养与ASD风险相关的估计比值比为1.81（95%置信区间，1.35 - 2.27；I² = 0%）。
结论
纳入研究的结果具有同质性。我们的研究结果表明，未进行母乳喂养是ASD的一个风险因素。这些结果提示了母乳喂养在降低儿童ASD风险方面的重要性。
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