4岁同卵双胞胎男孩同时出现特发性葡萄膜炎。
Simultaneous presentation of idiopathic uveitis in monozygotic 4-year-old twin boys.
作者信息
Baxter Sarah, Van Gelder Russell N, Cheung Jason C, Basiaga Matthew L
机构信息
Division of Rheumatology, Department of Pediatrics, University of Washington School of Medicine/Seattle Children's Hospital, Seattle, WA, USA.
Department of Ophthalmology, University of Washington School of Medicine, Seattle, Washington, USA.
出版信息
Am J Ophthalmol Case Rep. 2022 Jul 19;27:101666. doi: 10.1016/j.ajoc.2022.101666. eCollection 2022 Sep.
PURPOSE
To report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis with simultaneous onset.
OBSERVATIONS
Here we report monozygotic twin 4-year-old boys with chronic bilateral anterior uveitis. The boys had simultaneous onset of uveitis and identical features. Evaluation, including whole exome sequencing (WES), failed to reveal a specific causative etiology. Each patient responded well to immune modulation and achieved uveitis remission on methotrexate monotherapy off topical glucocorticoids.
CONCLUSIONS AND IMPORTANCE
From this case of monozygotic twin boys presenting with chronic uveitis, we conclude that monozygotic twins may warrant evaluation in the setting of idiopathic uveitis, especially in young patients unable to express an adequate history.
目的
报告一对4岁同卵双胞胎男孩同时发生慢性双侧前葡萄膜炎。
观察结果
我们在此报告一对患有慢性双侧前葡萄膜炎的4岁同卵双胞胎男孩。这两个男孩葡萄膜炎同时发病且特征相同。包括全外显子组测序（WES）在内的评估未能揭示具体的病因。每位患者对免疫调节反应良好，在停用局部糖皮质激素的情况下，甲氨蝶呤单药治疗使葡萄膜炎得到缓解。
结论与意义
从这例患有慢性葡萄膜炎的同卵双胞胎男孩病例中，我们得出结论，在特发性葡萄膜炎的情况下，同卵双胞胎可能需要进行评估，尤其是在无法提供充分病史的年轻患者中。
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