中国新乡一家三级医院痰液中分离出的[具体内容缺失]的分子特征分析
Molecular Characterization of Isolated from Sputum in a Tertiary Hospital in Xinxiang, China.
作者信息
Hao Yuqi, Jiang Yong'ang, Ishaq Hafiz Muhammad, Liu Wenke, Zhao Huajie, Wang Mingyong, Yang Fan
机构信息
Xinxiang Key Laboratory of Pathogenic Biology, Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, People's Republic of China.
Faculty of Veterinary and Animal Sciences, Muhammad Nawaz Shareef University of Agriculture, Multan, Pakistan.
出版信息
Infect Drug Resist. 2022 Jul 18;15:3829-3839. doi: 10.2147/IDR.S370006. eCollection 2022.
BACKGROUND
In clinical practice, is a common opportunistic pathogen responsible for nosocomial infection. This study aimed to analyze the trend of antimicrobial susceptibility and virulent characteristics of isolated from sputum. In clinics, data of the current study will help in the clinical treatment of infection.
RESULTS
The current research showed the resistance rates of the 20 isolates against 13 antibiotics ranged from 15.0% to 80.0%. The detection rate of extended spectrum β-lactamases (ESBLs) was up to 55%, while was the most prevalent ESBLs genes. Four strains (25.0%) of presented hypermucoviscous phenotype (HMV). Moreover, 18 strains (90.0%) showed the stronger biofilm-forming ability. were the most prevalent virulence genes in current research. Ten strains were found capsule typing and the higher genetic diversity of colonizing in this region. K exhibited a strong positive correlation with imipenem resistance, while K showed strong correlations with . Furthermore, HMV phenotype showed significantly negative correlations with multidrug-resistant.
CONCLUSION
In the hospital, the antibiotic resistance of (isolated from sputum samples) has a serious concern. Additionally, strains of show the higher genetic diversity.
背景
在临床实践中，[病原体名称未给出]是引起医院感染的常见机会性病原体。本研究旨在分析从痰液中分离出的[病原体名称未给出]的抗菌药物敏感性趋势和毒力特征。在临床上，本研究的数据将有助于[病原体名称未给出]感染的临床治疗。
结果
当前研究表明，20株[病原体名称未给出]分离株对13种抗生素的耐药率在15.0%至80.0%之间。超广谱β-内酰胺酶（ESBLs）的检出率高达55%，而[ESBLs基因名称未给出]是最常见的ESBLs基因。4株（25.0%）[病原体名称未给出]呈现高黏液性表型（HMV）。此外，18株（90.0%）表现出较强的生物膜形成能力。[毒力基因名称未给出]是当前研究中最常见的毒力基因。发现10株具有荚膜分型，且该地区定植的[病原体名称未给出]具有较高的遗传多样性。K型与亚胺培南耐药呈强正相关，而K型与[相关因素未给出]呈强相关。此外，HMV表型与多重耐药呈显著负相关。
结论
在医院中，（从痰液样本中分离出的）[病原体名称未给出]的抗生素耐药性令人严重担忧。此外，[病原体名称未给出]菌株表现出较高的遗传多样性。
需注意，原文中部分关键信息缺失（如具体病原体名称、部分基因名称、相关因素等），翻译可能会因信息不完整而略显模糊。
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