Clinical Microbiology Laboratory, 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China.
Emerg Microbes Infect. 2020 Dec;9(1):1771-1779. doi: 10.1080/22221751.2020.1799721.
Carbapenem-resistant (CRKP) is emerging as a worldwide public health concern; however, the long-term molecular epidemiological surveillance of clinical CRKP in China is limited. We conducted a retrospective observational study (2008-2018) to assess the prevalence, susceptibility, risk factors and molecular epidemiology of clinical CRKP isolates. We found the prevalence of CRKP increased from 2.5%, 2008 to 15.8%, 2018. CRKP were significantly more frequent among hospitalized patients from ICU, and it was significantly more likely to be isolated from the capital city (Hangzhou) and the patients aged ≥60 years. Additionally, seasons and specimen types were associated with CRKP infections The main CRKP sequence type (ST) was ST11, and was the most prevalent gene variant. Together these data reveal an increasing incidence and resistance trends among CRKP, especially the ST11- -CRKP, in Zhejiang, during 2008-2018. Our findings are important for hospitals to limit its dissemination and optimize antibiotic administration.
耐碳青霉烯肠杆菌科细菌（CRKP）的出现对全球公共卫生构成了威胁；然而，中国临床耐碳青霉烯肠杆菌科细菌的长期分子流行病学监测十分有限。本研究通过回顾性观察研究（2008-2018 年）评估了临床耐碳青霉烯肠杆菌科细菌分离株的流行率、药敏性、危险因素和分子流行病学。结果发现，耐碳青霉烯肠杆菌科细菌的流行率从 2008 年的 2.5%上升至 2018 年的 15.8%。耐碳青霉烯肠杆菌科细菌更常从 ICU 住院患者中分离，且更可能从省会城市（杭州）和 60 岁以上患者中分离。此外，季节和标本类型与耐碳青霉烯肠杆菌科细菌感染有关。主要的耐碳青霉烯肠杆菌科细菌序列型为 ST11，blakpc-2 是最常见的基因变异。这些数据表明，2008-2018 年期间，浙江地区耐碳青霉烯肠杆菌科细菌的发病率和耐药性呈上升趋势，尤其是 ST11- -CRKP。这些发现对医院限制其传播和优化抗生素管理非常重要。
