Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2022 Jul 25;37(29):e238. doi: 10.3346/jkms.2022.37.e238.
Despite the low prevalence of secondary bacterial infection in coronavirus disease 2019 (COVID-19) patients, most of them were administered antibiotic therapy empirically. However, the prognostic impact of empirical antibiotic therapy has not been evaluated. We conducted retrospective propensity score-matched case-control study of 233 COVID-19 patients with moderate to severe illnesses who required oxygen therapy and evaluated whether empirical antibiotic therapy could improve clinical outcomes. Empirical antibiotic therapy did not improve clinical outcomes including length of stay, days with oxygen requirement, the proportion of patients with increased oxygen demand, the proportion of patients who required mechanical ventilation, and overall mortality. This finding implies that routine administration of antibiotics for the treatment of COVID-19 is not essential and should be restricted.
尽管在 2019 冠状病毒病（COVID-19）患者中，继发细菌感染的患病率较低，但大多数患者仍接受经验性抗生素治疗。然而，经验性抗生素治疗的预后影响尚未得到评估。我们对 233 名需要氧疗的中重度 COVID-19 患者进行了回顾性倾向评分匹配的病例对照研究，评估了经验性抗生素治疗是否能改善临床结局。经验性抗生素治疗并未改善临床结局，包括住院时间、需要吸氧的天数、需要增加吸氧需求的患者比例、需要机械通气的患者比例以及总体死亡率。这一发现表明，常规使用抗生素治疗 COVID-19 并非必要，应加以限制。
