通过级联醚化/斯米尔 rearrangement 策略的六步连续流动合成双氯芬酸钠：解决批处理问题。
Six-Step Continuous Flow Synthesis of Diclofenac Sodium via Cascade Etherification/Smiles Rearrangement Strategy: Tackling the Issues of Batch Processing.
机构信息
Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China.
Shanghai Engineering Research Center of, Industrial Asymmetric Catalysis of Chiral Drugs, Shanghai, 200433, P. R. China.
出版信息
Chemistry. 2022 Aug 10;28(45):e202202097. doi: 10.1002/chem.202202097. Epub 2022 Jul 26.
Invited for the cover of this issue are Dang Cheng, Fener Chen and co-workers at Fudan University. The image depicts six-step continuous-flow synthesis of diclofenac sodium from commercially available aniline and chloroacetic acid in a desktop microchemical plant. Read the full text of the article at 10.1002/chem.202201420.
本期封面邀请了复旦大学的党成、陈芬儿及其同事。图片描绘了在台式微型化学工厂中，由商业可得的苯胺和氯乙酸经六步连续流合成双氯芬酸钠。阅读全文请点击 10.1002/chem.202201420。
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