Barata-Vallejo Sebastian, Bonesi Sergio M, Postigo Al
Departamento de Ciencias Químicas, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junin 954 CP, 1113, Buenos Aires, Argentina.
Istituto per la Sintesi Organica e la Fotoreattività ISOF, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129, Bologna, Italy.
Chemistry. 2022 Oct 18;28(58):e202201776. doi: 10.1002/chem.202201776. Epub 2022 Aug 11.
Direct fluoroalkoxylation reactions of (hetero)arenes, carbon-carbon multiple bonds, and substitution reactions at Csp carbon centers by CF O, CHF O, and (CF ) CFO groups are discussed. Emphasis on thermal radical, electron transfer, photocatalytic, electrochemical and redox-neutral radical methods are placed to accomplish fluoroalkoxylation reactions. All these methods employ either radical fluoroalkoxylating reagents or some nucleophilic trifluoromethoxylating sources of CF O. A summary of all these methods is provided in Table 2.
本文讨论了（杂）芳烃、碳-碳多重键的直接氟烷氧基化反应，以及CF₂O、CHF₂O和(CF₃)₂CFO基团在Csp碳中心的取代反应。重点介绍了通过热自由基、电子转移、光催化、电化学和氧化还原中性自由基方法来实现氟烷氧基化反应。所有这些方法均使用自由基氟烷氧基化试剂或一些亲核三氟甲氧基化的CF₃O来源。表2提供了所有这些方法的总结。
