Medi-Quality Security Institute (MQS), Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kyotanabe, Kyoto 610-0395, Japan.
AI Hospital/Macro Signal Dynamics Research and Development Center, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; Medicine Security Workshop, Venture Business Laboratory 4F, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.
J Pharm Biomed Anal. 2022 Sep 20;219:114940. doi: 10.1016/j.jpba.2022.114940. Epub 2022 Jul 14.
In recent years, cosmetics deemed equivalent to pharmaceutical products containing prostaglandin F (PGF) analogs have been distributed overseas in the form of eyelash serums that can be purchased via the internet. The purpose of this study was to investigate the presence or absence of PGF analogs in eyelash serums procured in Japan via the internet to elucidate the actual composition. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) measurement system was developed for the determination of 14 PGF analogs in cosmetic serums. In total, 64 eyelash serum samples were purchased from 34 websites. After pretreatment, eyelash serum samples were screened for PGF analogs using the LC-MS/MS system. Products containing PGF analogs were subjected to quantification of these compounds. Of the 64 products, four were found to contain bimatoprost, among which, three did not indicate their contents on their package labels. In contrast, no samples were found to contain latanoprost, travoprost, or tafluprost, which are prescribed for glaucoma treatment. Additionally, eight products contained other PGF analogs, which have not been used as pharmaceuticals. The ease of access to cosmetic serums containing PGF analogs via online purchases presents a risk of serious side effects, particularly when consumers are not informed of their contents on the packages. This issue requires serious consideration to avoid the incorporation of pharmaceutical substances into cosmetic products.
近年来，含有前列腺素 F（PGF）类似物的被认为等效于药物的化妆品以睫毛液的形式通过互联网在海外分发。本研究的目的是调查通过互联网在日本购买的睫毛液中是否存在 PGF 类似物，以阐明实际成分。开发了一种用于测定化妆品血清中 14 种 PGF 类似物的液相色谱-串联质谱（LC-MS/MS）测量系统。总共从 34 个网站购买了 64 个睫毛血清样本。经过预处理后，使用 LC-MS/MS 系统对睫毛血清样本进行 PGF 类似物筛查。对含有 PGF 类似物的产品进行这些化合物的定量分析。在 64 种产品中，有 4 种含有比马前列素，其中 3 种在其包装标签上未标明其含量。相比之下，没有发现含有拉坦前列素、曲伏前列素或他氟前列素的样本，这些药物用于治疗青光眼。此外，有 8 种产品含有其他未用作药物的 PGF 类似物。通过在线购买很容易获得含有 PGF 类似物的化妆品，这存在严重副作用的风险，尤其是当消费者在包装上未被告知其成分时。这个问题需要认真考虑，以避免将药物物质掺入化妆品中。
