Equine Health Studies Program, Baton Rouge, LA, USA.
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA.
J Equine Vet Sci. 2022 Oct;117:104085. doi: 10.1016/j.jevs.2022.104085. Epub 2022 Jul 23.
Supplements containing Cannabidiol (CBD) are available for horses, however, few studies have been published on their effects on behavior and health parameters. The purpose of this study was to determine if a daily oral supplement containing CBD would cause sedation, ataxia or alterations in other health parameters during administration for 56 days. Twenty clinically healthy adult Thoroughbred horses were housed in stalls. Before treatment was initiated, a complete physical examination, complete blood count (CBC) and biochemical panel were evaluated. In addition, horses were examined for sedation and ataxia using standard scoring systems. Horses were randomly divided into two treatment groups, treated (supplement pellets containing CBD as Hemp Extract, 150 mg) or control (supplement pellets without CBD). Horses were treated daily and sedation and ataxia scores were assigned by two masked observers once weekly for 56 days. Horses were monitored daily for clinical signs or adverse events and body weights were recorded weekly. A CBC and biochemical panel were repeated on days 28 and 56, two hours after administration of the supplement. The supplement was readily consumed by the horses and no adverse effects were seen over the treatment period. Sedation and ataxia scores ranged from zero to two for all horses during the weekly examinations and there was no statistical difference between treatment groups. There were no treatment effects on blood values, including indicators of anemia and blood proteins, liver enzymes, kidney values, electrolytes or calcium. Body weight significantly increased in all horses, by Day 56 compared to Day zero but no treatment by day effect was noted. The CBD supplement (150 mg) was readily consumed and safe and did not result in changes in mentation, gait, or other health parameters, and no adverse clinical signs were observed during 56 days of oral administration.
含有大麻二酚（CBD）的补充剂可用于马匹，但是，关于其对行为和健康参数的影响的研究很少。本研究的目的是确定每天口服含有 CBD 的补充剂是否会在 56 天的给药期间引起镇静，共济失调或其他健康参数的改变。二十匹临床健康的成年纯种马被安置在马厩中。在开始治疗之前，对其进行了全面的体格检查，全血细胞计数（CBC）和生化小组检查。此外，还使用标准评分系统检查了马匹的镇静和共济失调情况。马匹被随机分为两组，一组接受治疗（含有 CBD 的补充丸剂，作为大麻提取物，150mg），另一组为对照组（不含 CBD 的补充丸剂）。每天给马匹治疗，并在 56 天内每周一次由两名掩蔽观察者对镇静和共济失调评分进行评估。每天监测马匹的临床症状或不良事件，并每周记录体重。在给药后 2 小时，在第 28 天和第 56 天重复进行 CBC 和生化小组检查。该补充剂很受马匹欢迎，在整个治疗期间没有观察到不良反应。在每周检查期间，所有马匹的镇静和共济失调评分均为零至二，治疗组之间无统计学差异。血液值（包括贫血和血液蛋白，肝酶，肾值，电解质或钙的指标）无治疗作用。所有马匹的体重在第 56 天与第 0 天相比均显著增加，但未观察到治疗日效应。CBD 补充剂（150mg）很容易被马匹接受，并且安全，不会导致精神状态，步态或其他健康参数改变，在 56 天的口服给药期间未观察到不良临床症状。
