N-苯甲酰基咪唑与核糖核苷酸的反应机理。
The reaction mechanism of N-benzoylimidazole with ribonucleotides.
作者信息
Wang Y, Liu X Y, Yang Z W, Wang Q W, Xu Y Z, Wang Q Z, Xu J F
出版信息
Nucleic Acids Res. 1987 May 26;15(10):4291-305. doi: 10.1093/nar/15.10.4291.
Abstract
The reaction of uridine 3'-phosphate with benzoylimidazole in the absence and presence of a strong base was followed up by 31P and 1H nmr as well as paper electrophoresis. Possible reaction courses were proposed, the reaction rate constants were calculated and the reaction mechanism was discussed. It is possible to selectively acylate ribonucleotides with benzoylimidazole by appropriate choice of the base used.
摘要
在有无强碱存在的情况下，通过³¹P和¹H核磁共振以及纸电泳对3'-磷酸尿苷与苯甲酰咪唑的反应进行了跟踪。提出了可能的反应过程，计算了反应速率常数并讨论了反应机理。通过适当选择所用的碱，可以用苯甲酰咪唑选择性地酰化核糖核苷酸。
相似文献
1
The reaction mechanism of N-benzoylimidazole with ribonucleotides.N-苯甲酰基咪唑与核糖核苷酸的反应机理。
Nucleic Acids Res. 1987 May 26;15(10):4291-305. doi: 10.1093/nar/15.10.4291.
2
Some aspects of chemical synthesis of oligoribonucleotides.寡核糖核苷酸化学合成的某些方面。
Nucleic Acids Symp Ser. 1980(7):103-13.
3
Effects of metal ions, including Mg2+ and lanthanides, on the cleavage of ribonucleotides and RNA model compounds.包括Mg2+和镧系元素在内的金属离子对核糖核苷酸和RNA模型化合物裂解的影响。
Proc Natl Acad Sci U S A. 1991 May 15;88(10):4080-3. doi: 10.1073/pnas.88.10.4080.
4
Biomimetic aminoacylation of ribonucleotides and RNA with aminoacyl phosphate esters and lanthanum salts.核糖核苷酸和RNA与氨酰磷酸酯及镧盐的仿生氨酰化作用。
J Am Chem Soc. 2007 Dec 26;129(51):15848-54. doi: 10.1021/ja073976l. Epub 2007 Dec 4.
5
6
A tight binding inhibitor of 5-aminoimidazole ribonucleotide carboxylase.
J Med Chem. 1993 Oct 29;36(22):3484-6. doi: 10.1021/jm00074a033.
7
Solvation effects on the 31P-NMR chemical shifts and infrared spectra of phosphate diesters.溶剂化对磷酸二酯的31P核磁共振化学位移和红外光谱的影响。
Biopolymers. 1984 Nov;23(11 Pt 1):2157-72. doi: 10.1002/bip.360231105.
8
[Interaction of Ag+ ions with ribonucleotides of canonical bases].[Ag⁺离子与标准碱基的核糖核苷酸的相互作用]
Biofizika. 1999 Mar-Apr;44(2):208-15.
9
Probing the sensitivity of 31P NMR chemical shifts to hydrogen bonding and to stereochemistry.探究³¹P核磁共振化学位移对氢键和立体化学的敏感性。
FEBS Lett. 1979 Sep 1;105(1):11-4. doi: 10.1016/0014-5793(79)80876-5.
10
Biochemical studies of taste sensation. IX. Enhancement of L-[3H]glutamate binding to bovine taste papillae by 5'-ribonucleotides.味觉的生化研究。IX. 5'-核糖核苷酸对L-[3H]谷氨酸与牛味蕾结合的增强作用。
Biochim Biophys Acta. 1980 Feb 7;627(3):313-23.
本文引用的文献
1
The effect of substituents on the deacylation of benzoyl-chymotrypsins.取代基对苯甲酰基-胰凝乳蛋白酶脱酰作用的影响。
Biochemistry. 1962 Sep;1:883-93. doi: 10.1021/bi00911a022.
2
Some aspects of chemical synthesis of oligoribonucleotides.寡核糖核苷酸化学合成的某些方面。
Nucleic Acids Symp Ser. 1980(7):103-13.
3
Studies on polynucleotides. LI. Syntheses of the 64 possible ribotrinucleotides derived from the four major ribomononucleotides.多核苷酸的研究。第一部分。由四种主要核糖单核苷酸衍生而来的64种可能的核糖三核苷酸的合成。
J Am Chem Soc. 1966 Feb 20;88(4):819-29. doi: 10.1021/ja00956a039.
4
[Synthesis of dinucleotides in the ribose series with terminal 3'-phosphate groups].[具有末端3'-磷酸基团的核糖系列二核苷酸的合成]
Justus Liebigs Ann Chem. 1967 Apr;703:215-24. doi: 10.1002/jlac.19677030125.
5
Spectrophotometric determination of the pK values for dissociation of the sugar hydroxyls in pyrimidine arabinonucleosides.分光光度法测定嘧啶阿拉伯核苷中糖羟基解离的pK值。
Z Naturforsch C Biosci. 1975 Sep-Oct;30(5):565-70. doi: 10.1515/znc-1975-9-1003.
Zotero 插件