透明质酸包覆的 Bi:CuO：一种具有靶向递送和增强光热性能的 HS 响应型结肠癌治疗剂。

Hyaluronic acid-coated Bi:CuO: an HS-responsive agent for colon cancer with targeted delivery and enhanced photothermal performance.

机构信息

Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China.

Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai, 200234, China.

出版信息

J Nanobiotechnology. 2022 Jul 26;20(1):346. doi: 10.1186/s12951-022-01555-x.

BACKGROUND

Endogenous hydrogen sulfide (HS)-responsive theranostic agents have attracted extensive attention due to their specificity for colon cancer. However, the development of such agents with high enrichment in tumors and excellent photothermal performance remains challenging.

RESULTS

We prepared hyaluronic acid (HA)-coated Bi-doped cuprous oxide (Bi:CuO@HA) via a one-pot method. The HA specifically targets colon cancer tumor cells to improve the enrichment of Bi:CuO@HA at tumor sites, while the doped Bi both enhances the photothermal performance of the HS-triggered CuO and serves as an agent for tumor imaging. The results in this work demonstrated that the Bi:CuO@HA nanoparticles exhibit good biocompatibility, target colon cancer tumor cells, facilitate computed tomography imaging, and enhanced HS-responsive photothermal therapy performance, resulting in an excellent therapeutic effect in colon cancer.

CONCLUSIONS

The novel Bi:CuO@HA nanoparticles exhibit excellent tumor targeting and photothermal therapeutic effects, which provide new strategies and insights for colon cancer therapy.

背景

内源性硫化氢（HS）响应治疗剂因其对结肠癌的特异性而受到广泛关注。然而，开发具有高肿瘤富集和优异光热性能的此类试剂仍然具有挑战性。

结果

我们通过一锅法制备了透明质酸（HA）包覆的 Bi 掺杂氧化亚铜（Bi:CuO@HA）。HA 特异性靶向结肠癌肿瘤细胞，以提高 Bi:CuO@HA 在肿瘤部位的富集，而掺杂的 Bi 既增强了 HS 触发的 CuO 的光热性能，又可用作肿瘤成像剂。这项工作的结果表明，Bi:CuO@HA 纳米粒子具有良好的生物相容性，靶向结肠癌肿瘤细胞，促进计算机断层扫描成像，并增强 HS 响应光热治疗性能，从而在结肠癌的治疗中取得了优异的疗效。