Li Hai-Long, Deng Nian-Hua, He Xiu-Sheng, Li Yue-Hua
Key Laboratory of Cancer Cellular and Molecular Pathology in Hunan Province, Cancer Research Institute of Medical College, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, P.R. China.
Key Lab for Arteriosclerology of Hunan Province, International Joint Laboratory for Arteriosclerotic Disease Research of Hunan Province, Institute of Cardiovascular Disease, Hengyang Medical School, University of South China, 421001, Hengyang, Hunan, P.R. China.
Biomark Res. 2022 Jul 26;10(1):52. doi: 10.1186/s40364-022-00397-x.
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumours of the head and neck in Southeast Asia and southern China. The Phosphatidylinositol 3-kinase/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signalling pathway is involved in processes related to tumour initiation/progression, such as proliferation, apoptosis, metastasis, and drug resistance, and is closely related to the clinicopathological features of NPC. In addition, key genes involved in the PI3K/AKT/mTOR signalling pathway undergo many changes in NPC. More interestingly, a growing body of evidence suggests an interaction between this signalling pathway and microRNAs (miRNAs), a class of small noncoding RNAs. Therefore, in this review, we discuss the interactions between key components of the PI3K/AKT/mTOR signalling pathway and various miRNAs and their importance in NPC pathology and explore potential diagnostic biomarkers and therapeutic targets.
鼻咽癌（NPC）是东南亚和中国南方最常见的头颈部恶性肿瘤之一。磷脂酰肌醇3激酶/蛋白激酶B（AKT）/雷帕霉素哺乳动物靶蛋白（mTOR）信号通路参与肿瘤起始/进展相关过程，如增殖、凋亡、转移和耐药，且与鼻咽癌的临床病理特征密切相关。此外，PI3K/AKT/mTOR信号通路中的关键基因在鼻咽癌中发生许多变化。更有趣的是，越来越多的证据表明该信号通路与微小RNA（miRNA）（一类小的非编码RNA）之间存在相互作用。因此，在本综述中，我们讨论PI3K/AKT/mTOR信号通路关键组分与各种miRNA之间的相互作用及其在鼻咽癌病理学中的重要性，并探索潜在的诊断生物标志物和治疗靶点。
