Vézina-Audette Raphaël, Kantyka Marta, Gianotti Giacomo, Silverstein Deborah C
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital, 3900 Delancey Street, University of Pennsylvania, Philadelphia, PA 19104, USA.
Section of Anaesthesiology and Pain Therapy, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, 3012 Bern, Switzerland.
Animals (Basel). 2022 Jul 11;12(14):1781. doi: 10.3390/ani12141781.
The aim of this prospective, randomized, nonblinded, controlled clinical trial was to compare mean arterial blood pressure (MAP) and heart rate (HR) during an intravenous bolus of three different balanced isotonic crystalloid solutions in euvolemic, anesthetized dogs with hypotension. Thirty healthy dogs (American Society of Anesthesiologists Physical Status I-II) weighing at least 15 kg that presented for elective orthopedic or dental surgical procedures at the Ryan Veterinary Hospital for Small Animals of the University of Pennsylvania were included in this study. Anesthetized hypotensive patients (defined as a MAP ≤ 65 mmHg), were administered an infusion of Lactated Ringer's solution (LRS), Plasma-Lyte (PLYTE) or Canadian Plasma-Lyte (PLYTECA), selected at random. The infusion was administered over 15 min via a volumetric fluid pump. Differences in oscillometric MAP and HR between time points and across treatments were evaluated by mANOVA. Intravenous isotonic crystalloid infusions over 15 min did not significantly change MAP or HR in hypotensive dogs under general anesthesia. Neither LRS, PLYTE nor PLYTECA exacerbated hypotension or caused tachycardia.
这项前瞻性、随机、非盲、对照临床试验的目的是比较在静脉推注三种不同平衡等渗晶体溶液期间，处于血容量正常、麻醉状态且低血压的犬的平均动脉血压（MAP）和心率（HR）。本研究纳入了30只健康犬（美国麻醉医师协会身体状况分级为I-II级），体重至少15 kg，在宾夕法尼亚大学瑞安小动物兽医院接受择期骨科或牙科手术。将麻醉后的低血压患者（定义为MAP≤65 mmHg）随机给予乳酸林格氏液（LRS）、Plasma-Lyte（PLYTE）或加拿大Plasma-Lyte（PLYTECA）输注。通过容量输液泵在15分钟内完成输注。通过多因素方差分析评估各时间点及不同治疗组之间示波法测量的MAP和HR的差异。在全身麻醉下，15分钟内静脉输注等渗晶体溶液对低血压犬的MAP或HR无显著影响。LRS、PLYTE和PLYTECA均未加重低血压或引起心动过速。
