人胎儿和新生儿皮肤中的表皮朗格汉斯细胞和真皮树突状细胞：一项免疫组织化学研究。

Epidermal Langerhans' cells and dermal dendritic cells in human fetal and neonatal skin: an immunohistochemical study.

作者信息

Drijkoningen M, De Wolf-Peeters C, Van der Steen K, Moerman P, Desmet V

出版信息

Pediatr Dermatol. 1987 May;4(1):11-7. doi: 10.1111/j.1525-1470.1987.tb00745.x.

DOI:10.1111/j.1525-1470.1987.tb00745.x

Abstract

The dendritic cells in skin biopsies from 36 fetuses (from 16 weeks' gestational age on) and neonatal infants of different ages were investigated using a number of markers for various cells of the immune system and immunohistochemistry. Epidermal Langerhans' cells were found in all cases in a predominantly basal localization. The number of OKT6-positive Langerhans' cells and the development of their dendritic processes gradually increased with age. Dermal dendritic cells were present as well. Both HLA-DR-positive and Leu-10-positive dermal dendritic cells were found in the superficial and deep dermis, often in a perivascular distribution. The OKT6-positive dermal dendritic cells were few in number and occurred only in the upper dermis.

摘要

利用多种针对免疫系统不同细胞的标志物和免疫组织化学方法，对36例胎儿（从妊娠16周起）及不同年龄段新生儿的皮肤活检组织中的树突状细胞进行了研究。在所有病例中均发现表皮朗格汉斯细胞主要位于基底部位。OKT6阳性朗格汉斯细胞的数量及其树突状突起的发育随年龄逐渐增加。真皮树突状细胞也存在。在浅表和深部真皮中均发现了HLA - DR阳性和Leu - 10阳性的真皮树突状细胞，它们常呈血管周围分布。OKT6阳性真皮树突状细胞数量较少，仅出现在真皮上层。