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神经纤毛蛋白-1作为肝癌和结直肠癌预后及侵袭相关参数的潜在生物标志物：一项关于人体研究的系统评价和荟萃分析

Neuropilin-1 as a Potential Biomarker of Prognosis and Invasive-Related Parameters in Liver and Colorectal Cancer: A Systematic Review and Meta-Analysis of Human Studies.

作者信息

Fernández-Palanca Paula, Payo-Serafín Tania, Fondevila Flavia, Méndez-Blanco Carolina, San-Miguel Beatriz, Romero Marta R, Tuñón María J, Marin Jose J G, González-Gallego Javier, Mauriz José L

机构信息

Institute of Biomedicine (IBIOMED), Campus of Vegazana s/n, University of León, 24071 León, Spain.

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Av. de Monforte de Lemos 5, 28029 Madrid, Spain.

出版信息

Cancers (Basel). 2022 Jul 15;14(14):3455. doi: 10.3390/cancers14143455.

DOI:10.3390/cancers14143455
PMID:35884516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9318974/
Abstract

Neuropilin-1 (NRP1) is a transmembrane protein involved in numerous cellular functions which has had increasing interest from cancer researchers. Liver cancer and colorectal cancer (CRC) are two of the most frequent and deadly tumors with a complex pharmacological framework. Here, we assessed the prognostic, diagnostic and clinicopathological value of NRP1 in liver cancer and CRC patients. We searched PubMed, Scopus, Web of Science, Embase and Cochrane Library databases for articles evaluating the NRP1 correlation with survival parameters, tumor development or clinicopathological features. Hazard ratios and odds ratios with 95% confidence intervals were extracted or estimated by Parmar method and pooled to evaluate the overall effect size with STATA 16 software. Heterogeneity was analyzed by chi-square-based Q test and I statistic, along with meta-regression and subgroup analysis, and publication bias was assessed by funnel plot asymmetry and Egger's test. The study protocol was registered in PROSPERO (CRD42022307062). NRP1 overexpression was significantly correlated with lower survival in liver cancer patients and with tumor development in hepatocarcinoma patients, and was strongly correlated with an increased risk of vascular invasion in liver cancer and metastasis in CRC and liver tumors. These results support the role of NRP1 as a potential and useful biomarker in both types of cancer.

摘要

神经纤毛蛋白-1（NRP1）是一种参与多种细胞功能的跨膜蛋白，越来越受到癌症研究人员的关注。肝癌和结直肠癌（CRC）是两种最常见且致命的肿瘤，其药理学框架复杂。在此，我们评估了NRP1在肝癌和CRC患者中的预后、诊断及临床病理价值。我们在PubMed、Scopus、Web of Science、Embase和Cochrane图书馆数据库中搜索了评估NRP1与生存参数、肿瘤发展或临床病理特征相关性的文章。通过Parmar方法提取或估计95%置信区间的风险比和优势比，并使用STATA 16软件进行汇总以评估总体效应大小。通过基于卡方的Q检验和I统计量分析异质性，同时进行meta回归和亚组分析，并通过漏斗图不对称性和Egger检验评估发表偏倚。该研究方案已在PROSPERO（CRD42022307062）注册。NRP1过表达与肝癌患者较低的生存率以及肝癌患者的肿瘤发展显著相关，并且与肝癌中血管侵犯风险增加以及CRC和肝肿瘤转移风险增加密切相关。这些结果支持NRP1作为这两种癌症潜在且有用的生物标志物的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/98bd823d1909/cancers-14-03455-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/ae837b12ae88/cancers-14-03455-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/63686f10d1b9/cancers-14-03455-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/9e3110f962a5/cancers-14-03455-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/651ba9c42c2f/cancers-14-03455-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/98bd823d1909/cancers-14-03455-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/ae837b12ae88/cancers-14-03455-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/63686f10d1b9/cancers-14-03455-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/9e3110f962a5/cancers-14-03455-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/651ba9c42c2f/cancers-14-03455-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2333/9318974/98bd823d1909/cancers-14-03455-g005.jpg

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