Chen Yunhui, Ou Yangpan, Lv Dan, Yu Zengyan, Shang Tinghuizi, Ma Jidong, Zhan Chuang, Ding Zhenning, Yang Xu, Xiao Jian, Yang Ru, Sun Zhenghai, Zhang Guangfeng, Wang Xiaoping, Guo Wenbin, Li Ping
Department of Psychiatry, Qiqihar Medical University, Qiqihar 161006, China.
Department of Psychiatry, National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
Brain Sci. 2022 Jun 29;12(7):857. doi: 10.3390/brainsci12070857.
Functional abnormalities in brain areas within the fronto-limbic network have been widely reported in obsessive-compulsive disorder (OCD). However, region- and network-level brain activities of the fronto-limbic network at rest have not been simultaneously investigated in OCD. In this study, 40 medicine-free and non-comorbidity patients with OCD and 38 age-, education-, and gender-matched healthy controls (HCs) underwent a resting-state functional magnetic-resonance-imaging scan. Fractional amplitude of low-frequency fluctuations (fALFF), network homogeneity (NH), and support vector machine were used to analyze the data. Patients with OCD showed increased fALFF in the right orbital frontal cortex (OFC), increased NH in the left OFC, and decreased NH in the right putamen. Decreased NH of the right putamen was negatively correlated with the Y-BOCS total and compulsive behavior scores. Furthermore, a combination of NH in the left OFC and right putamen could be applied to differentiate OCD from HCs with optimum specificity and sensitivity. The current findings emphasize the crucial role of the fronto-limbic network in the etiology of OCD.
前额叶-边缘系统网络内脑区的功能异常在强迫症（OCD）中已被广泛报道。然而，强迫症患者静息状态下前额叶-边缘系统网络的区域和网络水平脑活动尚未同时进行研究。在本研究中，40名未服药且无合并症的强迫症患者和38名年龄、教育程度和性别匹配的健康对照者（HCs）接受了静息态功能磁共振成像扫描。采用低频振幅分数（fALFF）、网络同质性（NH）和支持向量机对数据进行分析。强迫症患者右侧眶额皮质（OFC）的fALFF增加，左侧OFC的NH增加，右侧壳核的NH减少。右侧壳核NH降低与Y-BOCS总分及强迫行为评分呈负相关。此外，左侧OFC和右侧壳核的NH组合可用于以最佳特异性和敏感性区分强迫症患者与健康对照者。目前的研究结果强调了前额叶-边缘系统网络在强迫症病因学中的关键作用。
