Rayudu Nithin Manohar, Subburaj Karupppasamy, Mohan Rajesh Elara, Sollmann Nico, Dieckmeyer Michael, Kirschke Jan S, Baum Thomas
Engineering Product Development (EPD) Pillar, Singapore University of Technology and Design (SUTD), Singapore 487372, Singapore.
Sobey School of Business, Saint Mary's University, 903 Robie St, Halifax, NS B3H 3C2, Canada.
Biomedicines. 2022 Jun 30;10(7):1567. doi: 10.3390/biomedicines10071567.
(1) Background: To study the feasibility of developing finite element (FE) models of the whole lumbar spine using clinical routine multi-detector computed tomography (MDCT) scans to predict failure load (FL) and range of motion (ROM) parameters. (2) Methods: MDCT scans of 12 subjects (6 healthy controls (HC), mean age ± standard deviation (SD): 62.16 ± 10.24 years, and 6 osteoporotic patients (OP), mean age ± SD: 65.83 ± 11.19 years) were included in the current study. Comprehensive FE models of the lumbar spine (5 vertebrae + 4 intervertebral discs (IVDs) + ligaments) were generated (L1−L5) and simulated. The coefficients of correlation (ρ) were calculated to investigate the relationship between FE-based FL and ROM parameters and bone mineral density (BMD) values of L1−L3 derived from MDCT (BMDQCT-L1-3). Finally, Mann−Whitney U tests were performed to analyze differences in FL and ROM parameters between HC and OP cohorts. (3) Results: Mean FE-based FL value of the HC cohort was significantly higher than that of the OP cohort (1471.50 ± 275.69 N (HC) vs. 763.33 ± 166.70 N (OP), p < 0.01). A strong correlation of 0.8 (p < 0.01) was observed between FE-based FL and BMDQCT-L1-L3 values. However, no significant differences were observed between ROM parameters of HC and OP cohorts (p = 0.69 for flexion; p = 0.69 for extension; p = 0.47 for lateral bending; p = 0.13 for twisting). In addition, no statistically significant correlations were observed between ROM parameters and BMDQCT- L1-3. (4) Conclusions: Clinical routine MDCT data can be used for patient-specific FE modeling of the whole lumbar spine. ROM parameters do not seem to be significantly altered between HC and OP. In contrast, FE-derived FL may help identify patients with increased osteoporotic fracture risk in the future.
(1) 背景：研究利用临床常规多排螺旋计算机断层扫描（MDCT）图像建立全腰椎有限元（FE）模型以预测失效载荷（FL）和运动范围（ROM）参数的可行性。(2) 方法：本研究纳入了12名受试者的MDCT图像（6名健康对照者（HC），平均年龄±标准差（SD）：62.16±10.24岁；6名骨质疏松患者（OP），平均年龄±SD：65.83±11.19岁）。建立并模拟了腰椎的综合有限元模型（5个椎体 + 4个椎间盘（IVD）+ 韧带）（L1 - L5）。计算相关系数（ρ）以研究基于有限元的FL和ROM参数与通过MDCT获得的L1 - L3骨密度（BMD）值（BMDQCT - L1 - 3）之间的关系。最后，进行Mann - Whitney U检验以分析HC组和OP组之间FL和ROM参数的差异。(3) 结果：HC组基于有限元的平均FL值显著高于OP组（1471.50±275.69 N（HC） vs. 763.33±166.70 N（OP），p < 0.01）。基于有限元的FL与BMDQCT - L1 - L3值之间观察到强相关性，相关系数为0.8（p < 0.01）。然而，HC组和OP组的ROM参数之间未观察到显著差异（屈曲时p = 0.69；伸展时p = 0.69；侧屈时p = 0.47；扭转时p = 0.13）。此外，ROM参数与BMDQCT - L1 - 3之间未观察到统计学上的显著相关性。(4) 结论：临床常规MDCT数据可用于全腰椎的个体化有限元建模。HC组和OP组之间的ROM参数似乎没有显著改变。相比之下，基于有限元的FL可能有助于未来识别骨质疏松性骨折风险增加的患者。
