文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

使用临床常规多排螺旋计算机断层扫描（MDCT）数据对全腰椎进行患者特异性有限元建模——一项初步研究

Patient-Specific Finite Element Modeling of the Whole Lumbar Spine Using Clinical Routine Multi-Detector Computed Tomography (MDCT) Data-A Pilot Study.

作者信息

Rayudu Nithin Manohar, Subburaj Karupppasamy, Mohan Rajesh Elara, Sollmann Nico, Dieckmeyer Michael, Kirschke Jan S, Baum Thomas

机构信息

Engineering Product Development (EPD) Pillar, Singapore University of Technology and Design (SUTD), Singapore 487372, Singapore.

Sobey School of Business, Saint Mary's University, 903 Robie St, Halifax, NS B3H 3C2, Canada.

出版信息

Biomedicines. 2022 Jun 30;10(7):1567. doi: 10.3390/biomedicines10071567.

DOI:10.3390/biomedicines10071567
PMID:35884872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9312902/
Abstract

(1) Background: To study the feasibility of developing finite element (FE) models of the whole lumbar spine using clinical routine multi-detector computed tomography (MDCT) scans to predict failure load (FL) and range of motion (ROM) parameters. (2) Methods: MDCT scans of 12 subjects (6 healthy controls (HC), mean age ± standard deviation (SD): 62.16 ± 10.24 years, and 6 osteoporotic patients (OP), mean age ± SD: 65.83 ± 11.19 years) were included in the current study. Comprehensive FE models of the lumbar spine (5 vertebrae + 4 intervertebral discs (IVDs) + ligaments) were generated (L1−L5) and simulated. The coefficients of correlation (ρ) were calculated to investigate the relationship between FE-based FL and ROM parameters and bone mineral density (BMD) values of L1−L3 derived from MDCT (BMDQCT-L1-3). Finally, Mann−Whitney U tests were performed to analyze differences in FL and ROM parameters between HC and OP cohorts. (3) Results: Mean FE-based FL value of the HC cohort was significantly higher than that of the OP cohort (1471.50 ± 275.69 N (HC) vs. 763.33 ± 166.70 N (OP), p < 0.01). A strong correlation of 0.8 (p < 0.01) was observed between FE-based FL and BMDQCT-L1-L3 values. However, no significant differences were observed between ROM parameters of HC and OP cohorts (p = 0.69 for flexion; p = 0.69 for extension; p = 0.47 for lateral bending; p = 0.13 for twisting). In addition, no statistically significant correlations were observed between ROM parameters and BMDQCT- L1-3. (4) Conclusions: Clinical routine MDCT data can be used for patient-specific FE modeling of the whole lumbar spine. ROM parameters do not seem to be significantly altered between HC and OP. In contrast, FE-derived FL may help identify patients with increased osteoporotic fracture risk in the future.

摘要

(1) 背景：研究利用临床常规多排螺旋计算机断层扫描（MDCT）图像建立全腰椎有限元（FE）模型以预测失效载荷（FL）和运动范围（ROM）参数的可行性。(2) 方法：本研究纳入了12名受试者的MDCT图像（6名健康对照者（HC），平均年龄±标准差（SD）：62.16±10.24岁；6名骨质疏松患者（OP），平均年龄±SD：65.83±11.19岁）。建立并模拟了腰椎的综合有限元模型（5个椎体 + 4个椎间盘（IVD）+ 韧带）（L1 - L5）。计算相关系数（ρ）以研究基于有限元的FL和ROM参数与通过MDCT获得的L1 - L3骨密度（BMD）值（BMDQCT - L1 - 3）之间的关系。最后，进行Mann - Whitney U检验以分析HC组和OP组之间FL和ROM参数的差异。(3) 结果：HC组基于有限元的平均FL值显著高于OP组（1471.50±275.69 N（HC） vs. 763.33±166.70 N（OP），p < 0.01）。基于有限元的FL与BMDQCT - L1 - L3值之间观察到强相关性，相关系数为0.8（p < 0.01）。然而，HC组和OP组的ROM参数之间未观察到显著差异（屈曲时p = 0.69；伸展时p = 0.69；侧屈时p = 0.47；扭转时p = 0.13）。此外，ROM参数与BMDQCT - L1 - 3之间未观察到统计学上的显著相关性。(4) 结论：临床常规MDCT数据可用于全腰椎的个体化有限元建模。HC组和OP组之间的ROM参数似乎没有显著改变。相比之下，基于有限元的FL可能有助于未来识别骨质疏松性骨折风险增加的患者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/d8989765009d/biomedicines-10-01567-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/292e742d55ef/biomedicines-10-01567-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/7e3ab7a8f554/biomedicines-10-01567-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/f4ea459b4969/biomedicines-10-01567-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/2591c5c0d2d9/biomedicines-10-01567-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/1ffe20c29311/biomedicines-10-01567-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/bf404bb2dd38/biomedicines-10-01567-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/672fc331dc06/biomedicines-10-01567-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/4c8070a1a368/biomedicines-10-01567-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/d8989765009d/biomedicines-10-01567-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/292e742d55ef/biomedicines-10-01567-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/7e3ab7a8f554/biomedicines-10-01567-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/f4ea459b4969/biomedicines-10-01567-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/2591c5c0d2d9/biomedicines-10-01567-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/1ffe20c29311/biomedicines-10-01567-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/bf404bb2dd38/biomedicines-10-01567-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/672fc331dc06/biomedicines-10-01567-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/4c8070a1a368/biomedicines-10-01567-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d81d/9312902/d8989765009d/biomedicines-10-01567-g009.jpg

相似文献

[1]
Patient-Specific Finite Element Modeling of the Whole Lumbar Spine Using Clinical Routine Multi-Detector Computed Tomography (MDCT) Data-A Pilot Study.

Biomedicines. 2022-6-30

[2]
MDCT-Based Finite Element Analyses: Are Measurements at the Lumbar Spine Associated with the Biomechanical Strength of Functional Spinal Units of Incidental Osteoporotic Fractures along the Thoracolumbar Spine?

Diagnostics (Basel). 2021-3-6

[3]
Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT.

Diagnostics (Basel). 2021-1-30

[4]
Prediction of incident vertebral fractures in routine MDCT: Comparison of global texture features, 3D finite element parameters and volumetric BMD.

Eur J Radiol. 2021-8

[5]
Multi-detector computed tomography (MDCT) imaging: association of bone texture parameters with finite element analysis (FEA)-based failure load of single vertebrae and functional spinal units.

Quant Imaging Med Surg. 2021-7

[6]
Predicting Vertebral Bone Strength Using Finite Element Analysis for Opportunistic Osteoporosis Screening in Routine Multidetector Computed Tomography Scans-A Feasibility Study.

Front Endocrinol (Lausanne). 2020

[7]
Effect of the intervertebral disc on vertebral bone strength prediction: a finite-element study.

Spine J. 2020-4

[8]
Converted lumbar BMD values derived from sagittal reformations of contrast-enhanced MDCT predict incidental osteoporotic vertebral fractures.

Calcif Tissue Int. 2012-4-7

[9]
Incorporating ligament laxity in a finite element model for the upper cervical spine.

Spine J. 2017-6-30

[10]
Low-dose and sparse sampling MDCT-based femoral bone strength prediction using finite element analysis.

Arch Osteoporos. 2020-2-22

引用本文的文献

[1]
Finite element fracture load analysis and dark-field X-ray imaging of osteoporotic and healthy vertebrae in human lumbar spine specimens.

BMC Musculoskelet Disord. 2025-6-3

[2]
Gender differences in L1 vertebral strength in adults 50+ using automated CT-based finite element analysis.

Sci Rep. 2025-3-28

[3]
Stress Distribution of Different Pedicle Screw Insertion Techniques Following Single-Segment TLIF: A Finite Element Analysis Study.

Orthop Surg. 2023-4

[4]
Development of a Computational Model of the Mechanical Behavior of the L4-L5 Lumbar Spine: Application to Disc Degeneration.

Materials (Basel). 2022-9-26

本文引用的文献

[1]
Proposed diagnostic volumetric bone mineral density thresholds for osteoporosis and osteopenia at the cervicothoracic spine in correlation to the lumbar spine.

Eur Radiol. 2022-9

[2]
MDCT-Based Finite Element Analysis for the Prediction of Functional Spine Unit Strength-An In Vitro Study.

Materials (Basel). 2021-10-3

[3]
Finite element analysis of the lumbar spine in adolescent idiopathic scoliosis subjected to different loads.

Comput Biol Med. 2021-9

[4]
Prediction of incident vertebral fractures in routine MDCT: Comparison of global texture features, 3D finite element parameters and volumetric BMD.

Eur J Radiol. 2021-8

[5]
Fusion versus nonfusion treatment for recurrent lumbar disc herniation.

J Craniovertebr Junction Spine. 2021

[6]
Comparison of the Characteristics of Back Pain in Women with Postmenopausal Osteoporosis with and without Vertebral Compression Fracture: A Retrospective Study at a Single Osteoporosis Center in Poland.

Med Sci Monit. 2021-2-18

[7]
Prediction of Incidental Osteoporotic Fractures at Vertebral-Specific Level Using 3D Non-Linear Finite Element Parameters Derived from Routine Abdominal MDCT.

Diagnostics (Basel). 2021-1-30

[8]
Predicting Vertebral Bone Strength Using Finite Element Analysis for Opportunistic Osteoporosis Screening in Routine Multidetector Computed Tomography Scans-A Feasibility Study.

Front Endocrinol (Lausanne). 2020

[9]
Automatic opportunistic osteoporosis screening in routine CT: improved prediction of patients with prevalent vertebral fractures compared to DXA.

Eur Radiol. 2021-8

[10]
Opportunistic Osteoporosis Screening Reveals Low Bone Density in Patients With Screw Loosening After Lumbar Semi-Rigid Instrumentation: A Case-Control Study.

Front Endocrinol (Lausanne). 2021-1-11

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索