DiMarco J P
Prog Clin Biol Res. 1987;230:271-81.
Since it has been recognized that adenosine had potent electrophysiologic effects, investigators in several laboratories have shown that it is useful for terminating episodes of PSVT that require AV nodal conduction for continuation and that it may be a useful diagnostic maneuver to expose the atrial mechanism in patients whose arrhythmias are not terminated. Preliminary experience suggests that acute intravenous use of adenosine is both safe and highly efficacious, but data systematically comparing it to other current modes of therapy are not yet available. Future goals of research will include further use of the drug for investigating the mechanisms of different supraventricular arrhythmias and development of either new methods of administration or new, longer-acting analogs that will permit chronic prophylactic therapy.
由于人们已经认识到腺苷具有强大的电生理作用，多个实验室的研究人员表明，它对于终止需要房室结传导才能持续的阵发性室上性心动过速（PSVT）发作很有用，而且对于揭示心律失常未被终止患者的心房机制可能是一种有用的诊断手段。初步经验表明，急性静脉使用腺苷既安全又高效，但尚未有将其与其他当前治疗方式进行系统比较的数据。未来的研究目标将包括进一步使用该药物来研究不同室上性心律失常的机制，以及开发新的给药方法或新的长效类似物以实现慢性预防性治疗。
