Ichimaru Y, Gomita Y
Pharmacology. 1987;34(2-3):176-80. doi: 10.1159/000138267.
Psychological stress produced by intraspecies emotional communication in a communication box was studied to see whether it could be applied to a new screening method for anti-ulcer agents. There were two groups of mice, the 'sender' mice that received electrical foot shocks and showed emotional responses such as piloerection, abnormal squealing and jumping, and the 'responder' mice that were affected by the sender's emotional responses without foot shock. The gastric lesions (erosions) produced by conditioned emotional stimuli were observed in both groups. The effects of the anti-ulcer drugs cetraxate, cimetidine and gefarnate were examined. In 'senders', the gastric lesions were significantly suppressed by the administration of cetraxate at a dose of 200 mg/kg (p.o.) or cimetidine at doses of 30 and 100 mg/kg (p.o.). The gastric lesions in 'responders' were significantly suppressed by two administrations of cetraxate at doses of 100 and 200 mg/kg (p.o.), cimetidine at doses of 10-100 mg/kg (p.o.) or gefarnate at a dose of 200 mg/kg (p.o.). The gastric lesions of 'responders' were more sensitive to anti-ulcer drugs. The present results indicate that the gastric erosions of 'responders' are useful for the evaluation of anti-ulcer agents.
研究了在交流箱中种内情绪交流产生的心理压力，以确定其是否可应用于抗溃疡药物的新筛选方法。有两组小鼠，一组是“发送者”小鼠，接受电足部电击并表现出竖毛、异常尖叫和跳跃等情绪反应；另一组是“反应者”小鼠，在无足部电击的情况下受到“发送者”情绪反应的影响。观察了两组小鼠中由条件性情绪刺激产生的胃部病变（糜烂）。检测了抗溃疡药物西曲酸酯、西咪替丁和吉法酯的效果。在“发送者”中，口服200mg/kg的西曲酸酯或口服30mg/kg和100mg/kg的西咪替丁可显著抑制胃部病变。在“反应者”中，口服100mg/kg和200mg/kg的西曲酸酯、口服10 - 100mg/kg的西咪替丁或口服200mg/kg的吉法酯，两次给药后可显著抑制胃部病变。“反应者”的胃部病变对抗溃疡药物更敏感。目前的结果表明，“反应者”的胃糜烂可用于评估抗溃疡药物。
