Gomita Y, Ichimaru Y, Ohizumi N, Yamada H, Moriyama M, Araki Y
Department of Hospital Pharmacy, Okayama University Medical School, Japan.
Acta Med Okayama. 1987 Dec;41(6):275-8. doi: 10.18926/AMO/31736.
The anti-ulcer action of clotiazepam (a thienodiazepine derivative) was studied in mice subjected to non-physical and physical stimuli in a communication box. There were two groups of mice: the "sender" mice that received electric shocks on the feet and responded by squealing and jumping, and the "responder" mice that were affected by the senders' responses without receiving shocks on the feet. Gastric ulcers resulted in both groups. The effect of clotiazepam was compared with that of diazepam. The incidence of gastric ulcers was suppressed by clotiazepam at a dose of 3 mg/kg, per os, in "responder" and "sender" mice, and by diazepam at a dose of 1 mg/kg, per os, in "responder" mice. These results suggest that clotiazepam has a suppressive action against gastric ulcers produced by non-physical or physical stimuli, although its potency is slightly weaker than that of diazepam.
在一个交流箱中，对经受非物理和物理刺激的小鼠研究了氯噻西泮（一种噻吩二氮卓衍生物）的抗溃疡作用。实验有两组小鼠：“发送者”小鼠会受到足部电击，并通过尖叫和跳跃做出反应；“反应者”小鼠受到“发送者”反应的影响，但足部未接受电击。两组小鼠均出现了胃溃疡。将氯噻西泮的效果与地西泮的效果进行了比较。在“反应者”和“发送者”小鼠中，口服3mg/kg剂量的氯噻西泮可抑制胃溃疡的发生率；在“反应者”小鼠中，口服1mg/kg剂量的地西泮可抑制胃溃疡的发生率。这些结果表明，氯噻西泮对非物理或物理刺激引起的胃溃疡具有抑制作用，尽管其效力略弱于地西泮。
