Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan.
School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien 97004, Taiwan.
Int J Environ Res Public Health. 2022 Jul 18;19(14):8710. doi: 10.3390/ijerph19148710.
Trimethylamine N-oxide (TMAO) is a gut microbial metabolite that affects atherogenesis and glucose dysregulation. The purpose of this study was to look at the link between blood TMAO levels and metabolic syndrome (MetS) in individuals with coronary artery disease (CAD). Blood samples were obtained in fasting status, and serum TMAO level was quantified by high-performance liquid chromatography-mass spectrometry. MetS and its components were defined according to the International Diabetes Federation diagnostic criteria. Of 92 enrolled patients, 51 (55.4%) had MetS. Patients with MetS had a greater proportion of hypertension and diabetes mellitus, higher body weight, waist circumference, body mass index, systolic blood pressure, fasting glucose, triglycerides, blood urea nitrogen, creatinine, C-reactive protein (CRP), insulin level, homeostasis model assessment of insulin resistance, and TMAO level. Multivariable logistic regression models revealed that TMAO level (odds ratio: 1.036, 95% confidence interval: 1.005-1.067, = 0.023) could be an effective predictor of MetS among the CAD population. In these patients, the log-TMAO level was positively associated with log-CRP (β = 0.274, = 0.001) and negatively associated with eGFR (β = -0.235, = 0.022). In conclusion, our study revealed a positive association between serum TMAO level and MetS among patients with CAD.
三甲胺 N-氧化物（TMAO）是一种肠道微生物代谢产物，它影响动脉粥样硬化和葡萄糖失调。本研究旨在观察冠心病患者血液 TMAO 水平与代谢综合征（MetS）之间的关系。在禁食状态下采集血液样本，并通过高效液相色谱-质谱法定量血清 TMAO 水平。MetS 及其成分根据国际糖尿病联合会的诊断标准定义。在 92 名入组患者中，有 51 名（55.4%）患有 MetS。患有 MetS 的患者中高血压和糖尿病的比例更高，体重、腰围、体重指数、收缩压、空腹血糖、甘油三酯、血尿素氮、肌酐、C 反应蛋白（CRP）、胰岛素水平、胰岛素抵抗的稳态模型评估、TMAO 水平更高。多变量逻辑回归模型显示，TMAO 水平（比值比：1.036，95%置信区间：1.005-1.067， = 0.023）是 CAD 人群中 MetS 的有效预测因子。在这些患者中，log-TMAO 水平与 log-CRP 呈正相关（β = 0.274， = 0.001），与 eGFR 呈负相关（β = -0.235， = 0.022）。总之，我们的研究揭示了冠心病患者血清 TMAO 水平与 MetS 之间存在正相关。
